His program of research spans several aspects of ageing health. His primary interest is in the study of risk factors and mechanisms underlying dementia, particularly with respect to vascular and metabolic health. He has also led the field in the study of the impact of brain ageing on impaired mobility and the risk of falls, and in the link between brain ageing, gait and cognition. He actively collaborates in large scale initiatives in the genetics of brain ageing and risk stratification for the secondary prevention of stroke.