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A major interest of our laboratory is in understanding how cells in metazoan organisms manage to target ion channels to physiological sites that optimize their physiological efficiency. Our research began with discovery of the ankyrin family of membrane-adapter proteins, which interact with structurally diverse membrane proteins and couple these proteins to the spectrin-based membrane skeleton. Currently identified ankyrin partners are anion exchangers, the Na/K ATPase, the voltage-dependent sodium channel, and the Na/Ca exchanger. Ankyrin(s) also associate with calcium-release channels including both IP3 and ryanodine receptors. Finally, ankyrins also bind to cell adhesion molecules of the L1 CAM family (L1/neurofascin/NrCAM/NgCAM in vertebrates; neuroglian in Drosophila; LAD-1 in C. elegans). Ankyrins interact with these diverse proteins through a motif known as ANK repeats, which are found in many different proteins and operate in protein recognition for multiple structurally unrelated ligands.
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Christian Thome, Jan Maximilian Janssen, Seda Karabulut,Claudio Acuna,Elisa D'Este,Stella J. Soyka, Konrad Baum, Michael Bock,Nadja Lehmann,Dan Alin Ganea,Chloé Maëlle Benoit,Jan Gründemann,
biorxiv(2023)
Proceedings of the National Academy of Sciences of the United States of Americano. 31 (2019): 15686-15695
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A. D. Nelson, R. N. Caballero-Florán,J. C. Rodríguez Díaz,J. M. Hull, Y. Yuan,J. Li,K. Chen, K. K. Walder, L. F. Lopez-Santiago,V. Bennett,M. G. McInnis,L. L. Isom,
Rui Yang,Kathryn K Walder-Christensen, Samir Lalani,Haidun Yan,Irene Díez García-Prieto,Sara Álvarez,Alberto Fernández-Jaén, Laura Speltz,Yong-Hui Jiang,Vann Bennett
Proceedings of the National Academy of Sciences of the United States of Americano. 39 (2019): 19717-19726
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