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The central theme of our research program is the antigenicity of proteins that are targets of paraneoplastic autoimmunity. Synaptic plasma membrane cation channels and neurotransmitter receptors are of particular interest because they readily interact with circulating antibodies. Molecules that are used by tumors for autocrine growth, and possibly metastasis, are in many cases identical to the signaling molecules used by nerve and muscle cells in communicating with each other. The specific antigens we are studying are voltage-gated calcium and potassium channels, nicotinic acetylcholine receptors, and related molecules expressed in carcinomas of lung and ovary, and epithelial thymomas. Tumor proteins of this type initiate the helper T lymphocyte-dependent production of autoantibodies that impair synaptic transmission in the central and peripheral nervous systems.
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Masoud Majed,Cristina Valencia Sanchez,Jeffrey L Bennett,James Fryer, Martin D Mulligan, Vyankya Redenbaugh,Andrew McKeon,John R Mills,Dean M Wingerchuk,Vanda A Lennon,Brian Weinshenker,John J Chen,
Annals of neurology (2023)
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NEUROLOGYno. 23 (2022): S31-S32
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M. Bakri Hammami,Grayson Beecher,Andrew Knight,Teerin Liewluck,James Triplett,Abhigyan Datta,Surendra Dasari, Youwen Zhang,Matthew Roforth, Calvin Jerde,Stephen Murphy,William Litchy,
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Divyanshu Dubey,Grayson Beecher,M Bakri Hammami,Andrew M Knight,Teerin Liewluck,James Triplett,Abhigyan Datta,Surendra Dasari, Youwen Zhang,Matthew M Roforth, Calvin R Jerde,Stephen J Murphy,
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