Proteins widely conserved in eukaryotic lineages play fundamentally important roles in the shared, basic mechanisms of life. The success of many scientific pursuits in biology from basic science to drug discovery depend increasingly on the comprehensive representation of an organism's biology. A complete understanding of protein components conserved throughout eukaryotes would have far-reaching benefits for biological research on a wide range of scales. However, despite almost a century of gene- and gene product-specific genetic and biochemical investigation the roles of many broadly conserved proteins remain unknown. PomBase provides an inventory of "Priority unstudied genes" conserved from fission yeast to vertebrates. We recently published preliminary inventories proteins of "unknown biological role" in yeast (fission and budding) and human using a scalable and maintainable method based on GO process slims.