基本信息
浏览量:13
职业迁徙
个人简介
Our main scientific interest lies in the field of plant-microbe interactions. We are in particularly interested in understanding how pathogen perception leads to reprogramming of gene expression. Through evolution plants have evolved two strategies of pathogen perception, extracellular recognition of pathogen-associated molecular patterns (PAMPs) by trans-membrane pattern recognition receptors (PRRs) and intracellular recognition of effectors by multi-domain resistance (R) proteins. Despite our understanding of how plants perceive pathogens, little is known about the downstream responses leading to reprogramming of gene expression.
Upon pathogen perception, plant cells are faced with the challenge to reallocate their limited resources and quickly change their state of gene transcription with the minimum cost on other biological processes. Chromatin remodelling is now recognized as a major mechanism controlling gene expression and a point of cross talk between different pathways. Chromatin remodelling requires histone covalent modifications and/or the action of ATP-dependent remodelling complexes.
We use the model pathosystem consisting of the host Arabidopsis thaliana and the bacterial pathogen Pseudomonas syringae in combination with genome-wide approaches such as mRNA-seq and ChIP-seq, confocal microscopy and biochemistry to identify how pathogen perception leads to chromatin remodelling that ultimately controls gene expression. An understanding of how chromatin remodelling regulates plant immune responses will be an important step towards engineering plants with durable resistance and increased crop yields.
研究兴趣
论文共 44 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Environmental microbiomeno. 1 (2023): 1-13
Jamie Harrison, Rana Muhammad Fraz Hussain,Shannon F Greer,Vardis Ntoukakis,Andrew Aspin,Joana G Vicente,Murray Grant,David J Studholme
Access microbiologyno. 7 (2023)
引用0浏览0WOS引用
0
0
Rory Osborne, Laura Rehneke,Silke Lehmann, Jemma Roberts,Melina Altmann,Stefan Altmann, Yingqi Zhang, Eva Köpff,Ana Dominguez-Ferreras, Emeka Okechukwu,Chrysi Sergaki,Charlotte Rich-Griffin,
Nature communicationsno. 1 (2023): 4065-16
Nature Communicationsno. 1 (2023): 1-11
引用3浏览0WOSNATURE引用
3
0
Morgan Lee, Anna Dominguez-Ferreras,Ewon Kaliyadasa,Wei-Jie Huang,Edna Antony, Tracey Stevenson,Silke Lehmann,Patrick Schäfer,Marc R Knight,Vardis Ntoukakis,Heather Knight
引用0浏览0引用
0
0
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn