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The research group of Brain Development and Disease is driven by a fascination of the mind and its matter. The group focuses on the mechanisms involved in neurodevelopment, systemic inflammation, and neurodegenerative diseases such as dementia and Alzheimer’s disease.
We apply methods such as single cell RNA sequencing to understand the cellular diversity of the part of the brain where Alzheimer’s disease first strikes called the entorhinal cortex. Single cell RNA sequencing data has enabled us to develop a novel neuron (brain) cell type from pluripotent stem cells using an approach called direct programming. These cells may provide clues as to why some cells in the brain are more vulnerable to disease than others. Uncovering the cellular diversity of the brain provides extraordinary insight into the complexity of this organ and provides us new evidence for the function and origins of brain diseases.
Our lab is also interested in the importance of the systemic immune environment, especially the gut, its microbiota and infections, and the role these have in the onset of neurodegenerative diseases
Current Research Interests:
Modeling Alzheimer's disease in a dish using pluripotent stem cells
Determining the origins of Alzheimer's disease
Understanding the development and evolution of the brain's spatial navigation.
Developing clean meat using animal stem cells
We apply methods such as single cell RNA sequencing to understand the cellular diversity of the part of the brain where Alzheimer’s disease first strikes called the entorhinal cortex. Single cell RNA sequencing data has enabled us to develop a novel neuron (brain) cell type from pluripotent stem cells using an approach called direct programming. These cells may provide clues as to why some cells in the brain are more vulnerable to disease than others. Uncovering the cellular diversity of the brain provides extraordinary insight into the complexity of this organ and provides us new evidence for the function and origins of brain diseases.
Our lab is also interested in the importance of the systemic immune environment, especially the gut, its microbiota and infections, and the role these have in the onset of neurodegenerative diseases
Current Research Interests:
Modeling Alzheimer's disease in a dish using pluripotent stem cells
Determining the origins of Alzheimer's disease
Understanding the development and evolution of the brain's spatial navigation.
Developing clean meat using animal stem cells
研究兴趣
论文共 82 篇作者统计合作学者相似作者
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biorxiv(2021)
C Goldeman,M Andersen, A Al-Robai, T Buchholtz, N Svane,B Ozgür,B Holst,E Shusta,V Hall,L Saaby,P Hyttel,B Brodin
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