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Vincent Falanga’s remarkable research career began in the fields of molecular and cell biology, evolving over the years to groundbreaking human-based translational research. He made seminal contributions to the expansion and growth of single cells in low oxygen tension and to the effects and transcriptional regulation of transforming growth factor-ß 1 (TGF-ß1). Dr. Falanga later focused his efforts on human recombinant growth factors and was the first to use a recombinant growth factor (EGF) in human non-healing wounds. He showed that systemic anabolic steroids can heal the painful skin ulcers due to cryofibrinogenemia and that doubling the dose of systemically administered pentoxifylline will heal venous ulcers. In 1998, he was the lead author in the use of living bioengineered skin in non-healing wounds, which led to the first ever FDA approval of bioengineered skin for accelerating wound closure. In 2007, he was the first to successfully use autologous cultured bone marrow-derived mesenchymal stem cells in human chronic wounds. In his new role as the Department of Dermatology’s Vice Chair for Research, Dr. Falanga will spearhead and coordinate many of the research projects related to tissue injury, repair processes, and regeneration. The School of Medicine and the Department of Dermatology are currently building a Good Manufacturing Practice (GMP) facility in which Dr. Falanga will oversee the research and development of novel treatments utilizing the therapeutic potential of stem cells in the care of chronic wounds caused by disorders ranging from diabetes to autoimmune disease. The GMP facility promises to enrich the translational capabilities of the Medical Center in Dermatology and other specialties.
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论文共 293 篇作者统计合作学者相似作者
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Maki Kida, Iqra Fatima, Elena Rozhkova,Marta Otero-Vinas,Muzhou Wu,Jay H. Kalin,Philip A. Cole,Vincent Falanga,Rhoda M. Alani,Andrey A. Sharov
JOURNAL OF INVESTIGATIVE DERMATOLOGYno. 2 (2024): 378-386.e2
William J. Nahm, Gail de Imus, Christopher A. Mathe,Liliana Saap, Saiyan Joseph,Stanley Chen,Vincent Falanga
JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGYno. 3 (2023): AB205-AB205
Maki Kida, Iqra Fatima, Elena Rozhkova,Marta Otero-Viñas,Muzhou Wu,Jay H. Kalin,Philip A. Cole,Vincent Falanga,Rhoda M. Alani, Andrey A. Sharov
Journal of Investigative Dermatology (2023)
William J Nahm, Gail de Imus, Christopher A Mathe,Liliana Saap,Saiyan Joseph,Stanley Chen,Vincent Falanga
SAGE open medical case reports (2023): 2050313X231200967-2050313X231200967
JOURNAL OF WOUND CAREno. 12 (2022): 1015-1015
Stem Cell Therapy for Autoimmune Diseasepp.55-58, (2019)
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