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个人简介
Our research uses mass spectrometry to discover and characterise new lipids (fats) made by circulating vascular cells that regulate immune defence and blood clotting.
Recently we showed that human blood platelets generate a large number of oxidized phospholipids several of which help clotting factors in plasma work more effectively. We also uncovered a new role for phospholipases in providing energy to the cell and how lipids in different people respond individually to aspirin.
Our current research is focused on understanding the role of new lipids in vascular inflammation including cardiovascular disease, dementia and wound healing. Some lipids we discovered are being developed as the basis of new treatments for bleeding excess. Other lipids we showed are anti-inflammatory are being developed as treatments for vascular inflammation, licensed to Complexa Inc, and with a $62M Series C funding investment in 2016
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论文共 175 篇作者统计合作学者相似作者
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Progress in Lipid Researchpp.101276-101276, (2024)
Ali A. Hajeyah,Majd B. Protty,Divyani Paul,Daniela Costa,Nader Omidvar, Bethan Morgan, Yugo Iwasaki, Beth McGill, P. Vincent Jenkins,Zaheer Yousef,Keith Allen-Redpath, Shin Soyama,
JOURNAL OF LIPID RESEARCHno. 1 (2024): 100484-100484
Matthew J. Conroy,Robert M. Andrews,Simon Andrews, Lauren Cockayne,Edward A. Dennis,Eoin Fahy,Caroline Gaud,William J. Griffiths, Geoff Jukes, Maksim Kolchin, Karla Mendivelso,Andrea F. Lopez-Clavijo,
NUCLEIC ACIDS RESEARCHno. D1 (2024): D1677-D1682
Ross J. Burton,Loic Raffray, Linda M. Moet,Simone M. Cuff,Daniel A. White,Sarah E. Baker, Bernhard Moser,Valerie B. O'Donnell, Peter Ghazal,Matt P. Morgan, Andreas Artemiou,Matthias Eberl
CLINICAL AND EXPERIMENTAL IMMUNOLOGYno. 3 (2024): 293-306
ALLERGY (2024)
Richard Skone,Daniel White,Bethan Phillips,Jennifer Evans,Robert Andrews,Benjamin Saunders,Kerry Hood,Mallinath Chakraborty,Sarah Edkins,Barbara Paquete,Sian Foulkes, Anna Barrow,
medRxiv (Cold Spring Harbor Laboratory) (2023)
Mass Spectrometry for Lipidomicspp.317-350, (2023)
Arteriosclerosis, thrombosis, and vascular biologyno. 9 (2023): 1700-1712
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