基本信息
浏览量:9
职业迁徙
个人简介
When we remember things, we activate an extensive array of events in the brain. Sensory input triggers whole-brain activity, which cascades through networks of brain cells. A torrent of electrical and chemical signals is launched in each cell, giving rise to changes in structures and connections between cells.
A key aspect of memory is the ability to relate events that occur in sequences, such as landmarks, music, movements, or words in a sentence. We study how such sequences are formed during learning, how sequences cause changes in cells and connections, and how molecular and electrical signals encode and sustain memories.
We use the new technique of optogenetics to monitor, as well as stimulate, brain cell activity using light. We can literally watch brain activity during learning, to see how sequences in the real world map to sequences in the brain. We replicate such sequences by projecting light patterns onto brain tissue slices, and ask how cells ‘learn’. Because these processes are so intertwined and complex, we use computer models to see how events at many levels of brain function give rise to memory. We have developed a major simulation tool called MOOSE, to build computer models from molecules to networks.
A key aspect of memory is the ability to relate events that occur in sequences, such as landmarks, music, movements, or words in a sentence. We study how such sequences are formed during learning, how sequences cause changes in cells and connections, and how molecular and electrical signals encode and sustain memories.
We use the new technique of optogenetics to monitor, as well as stimulate, brain cell activity using light. We can literally watch brain activity during learning, to see how sequences in the real world map to sequences in the brain. We replicate such sequences by projecting light patterns onto brain tissue slices, and ask how cells ‘learn’. Because these processes are so intertwined and complex, we use computer models to see how events at many levels of brain function give rise to memory. We have developed a major simulation tool called MOOSE, to build computer models from molecules to networks.
研究兴趣
论文共 137 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
biorxiv(2024)
Current opinion in neurobiology (2023): 102808-102808
medRxiv (Cold Spring Harbor Laboratory) (2023)
引用0浏览0引用
0
0
Current opinion in neurobiology (2023): 102729-102729
eNeurono. 3 (2023): 21-21
BMC Bioinformaticsno. 1 (2023): 1-24
Bernard ’t Hart,Titipat Achakulvisut, Ayoade Adeyemi,Athena Akrami,Bradly Alicea,Alicia Alonso-Andres,Diego Alzate-Correa,Arash Ash,Jesus Ballesteros,Aishwarya Balwani, Eleanor Batty,Ulrik Beierholm,
Journal of Open Source Educationno. 49 (2022)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn