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个人简介
Dr. Moll is a physician scientist at Stony Brook University and a leader in the field of the p53/p63/p73 gene family, studying their function and regulation in cancer, normal development and tissue homeostasis. She is board certified in Anatomical and Clinical Pathology and maintains part-time clinical duties in the Dept. of Pathology at SBU. She is the senior Principal Investigator of a continuously productive, well-funded research laboratory, and completed numerous successful projects with uninterrupted grant support from the National Cancer Institute, the National Heart, Lung, Blood Institute and other national foundations. Dr. Moll has broad experience in querying biological systems to decipher mechanisms of disease, ranging from human tissues, advanced cell culture to genetic mouse models that her lab engineers. She uses a broad range of multi-omic molecular, computational, cell biological and biochemical methods. Her lab generates new knockin mice and uses compound genetic mouse models to answer biological questions in vivo. Her research is published in top-ranked scientific journals.
Her lab made seminal contributions to the important field of p53, the premier tumor suppressor that protects our tissues from becoming cancerous, as well as its subversive tumor-promoting role when p53 is mutated in cancer. She discovered two separate transcription-independent cell death functions of wild-type p53, unexpectedly taking place outside the nucleus at the mitochondria. In response to a broad spectrum of cell stress, p53 protein induces programmed cell death of damaged cells (apoptosis) directly at the mitochondrial outer membrane by physical interactions with members of the Bcl2 family which control mitochondrial permeability. Her lab also identified a critical role of hypoxia-accumulated p53 protein in the mitochondrial matrix in triggering oxidative necrosis and ischemic stroke by directly opening the inner mitochondrial permeability transition pore via CypD activation.
研究兴趣
论文共 225 篇作者统计合作学者相似作者
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Tamara Isermann, Kim Lucia Schneider, Florian Wegwitz,Tiago De Oliveira,Lena-Christin Conradi,Valery Volk,Friedrich Feuerhake, Björn Papke,Sebastian Stintzing, Bettina Mundt, Florian Kühnel,Ute M Moll,
bioRxiv : the preprint server for biology (2024)
Ana Paula Delgado,Alice Nemajerova, Brian J. Nelson,Manisha Rao,Jinyu Li,Natalia Marchenko,Jonathan Preall,Ute M. Moll,Mikala Egeblad,Scott Powers
biorxiv(2024)
Christopher Maximilian Arends, Klara Kopp,Raphael Hablesreiter, Natalia Estrada,Friederike Christen,Ute Martha Moll,Robert Zeillinger,Wolfgang Daniel Schmitt,Jalid Sehouli,Hagen Kulbe, Maximilian Fleischmann, Isabelle Ray-Coquard,
LEUKEMIApp.1-12, (2024)
crossref(2023)
crossref(2023)
crossref(2023)
crossref(2023)
Bing Z. Carter,Po Yee Mak,Muharrem Müftüoğlu,Wenjing Tao,Ke Baozhen,Peixin Jiang, Andrea D Bedoy,Lauren B Ostermann, Yuichiro Nishida, Sevinj Isqandarova,Mary Sobieski,Nghi Nguyen,
Bloodno. 12 (2023): 1056-1070
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