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个人简介
Dr. Jacks’ research has focused on developing new methods for the construction and characterization of genetically engineered mouse models or GEMMs of human cancer, and recently has moved into the burgeoning area of tumor immunology to understand the interactions between the immune system and cancer. His group has produced GEMMs with constitutive and conditional mutations in several tumor suppressor genes, oncogenes, and genes involved in oxidative stress, DNA repair and epigenetic control of gene expression. These GEMMS have been used to examine the mechanism of tumor initiation and progression, to uncover the molecular, genetic and biochemical relationship to the human diseases, as tools to study response and resistance to chemotherapy, and to explore methods in molecular imaging and early detection of cancer.
研究兴趣
论文共 658 篇作者统计合作学者相似作者
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Chen Weng,Fulong Yu,Dian Yang,Michael Poeschla,L. Alexander Liggett,Matthew G. Jones,Xiaojie Qiu,Lara Wahlster,Alexis Caulier, Jeffrey A. Hussmann,Alexandra Schnell, Kathryn E. Yost,
Cancer discoveryno. 4 (2024): 563-568
Eric Sweet-Cordero,Kieren Marini, Emma Champion,Alex Lee, Isabelle Young,Stanley Leung, Nicolas Mathey-Andrews,Tyler Jacks,Peter Jackson,Jennifer Cochran
Research square (2024)
Zackery A. Ely, Zachary J. Kulstad, Eva K. Verzani,Jennifer G. Abelin, Sudarsana Addepalli,Karl R. Clauser, Marta Casarrubios,Kevin S. Kapner, Miles P. Agus,Connor J. Hennessey, Sine R. Hadrup,Susan Klaeger,
CANCER RESEARCHno. 2 (2024)
Carina Shiau, Jingyi Cao, Mark T. Gregory, Dennis Gong,Xunqin Yin,Jae-Won Cho,Peter L. Wang,Jennifer Su,Steven Wang,Jason W. Reeves,Tae Kyung Kim,Youngmi Kim,
CANCER RESEARCHno. 2 (2024)
Zackery A. Ely, Nicolas Mathey-Andrews,Santiago Naranjo, Samuel I. Gould, Kim L. Mercer,Gregory A. Newby, Christina M. Cabana,William M. Rideout III, Grissel Cervantes Jaramillo,Jennifer M. Khirallah, Katie Holland, Peyton B. Randolph,
Nature Biotechnologyno. 3 (2024): 424-436
Science advancesno. 1 (2024): eadj9591-eadj9591
Natureno. 8004 (2024): 636-645
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