Tsonwin Hai

Department of Biochemistry and Molecular Biology Harvard University Cambridge, Massachusetts 02138 USA

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Papers60 papers

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JDP2 and ATF3 deficiencies dampen maladaptive cardiac remodeling and preserve cardiac function.

Roy Kalfon,Tom Friedman, Shir Eliachar,Rona Shofti,Tali Haas,Lilach Koren, Jacob D Moskovitz,Tsonwin Hai,Ami Aronheim

PloS one, no. 2 (2019)

WOSBibtex

Endothelial Regeneration of Large Vessels Is a Biphasic Process Driven by Local Cells with Distinct Proliferative Capacities.

Austin I McDonald, Aditya S Shirali, Raquel Aragón, Feiyang Ma, Gloria Hernandez, Don A Vaughn,Julia J Mack, Tiffany Y Lim, Hannah Sunshine,Peng Zhao,Vladimir Kalinichenko,Tsonwin Hai

Cell stem cell, no. 2 (2018): 210

Cited by9WOSBibtex

Chemotherapy-Exacerbated Breast Cancer Metastasis: A Paradox Explainable by Dysregulated Adaptive-Response

Justin Middleton,Daniel Stover,Tsonwin Hai

International Journal of Molecular Sciences, no. 11 (2018): 3333

Cited by1Bibtex

Stress-inducible gene Atf3 in the noncancer host cells contributes to chemotherapy-exacerbated breast cancer metastasis

Yi Seok Chang,Swati P. Jalgaonkar,Justin D. Middleton,Tsonwin Hai

Proceedings of the National Academy of Sciences of the United States of America, no. 34 (2017): E7159-E7168

Cited by11WOSBibtex

Activating transcription factor 3 attenuates chemokine and cytokine expression in mouse skeletal muscle after exercise and facilitates molecular adaptation to endurance training

Rodrigo Fernández-Verdejo, Aline M. Vanwynsberghe,Ahmed Essaghir,Jean-Baptiste Demoulin,Tsonwin Hai,Louise Deldicque,Marc Francaux

The FASEB Journal, no. 2 (2017): 840-851

Cited by3Bibtex

Atf3 deficiency promotes genome instability and spontaneous tumorigenesis in mice.

Z Wang, Y He, W Deng,L Lang, H Yang, B Jin,R Kolhe,H-F Ding,J Zhang,T Hai,C Yan

Oncogene, (2017)

Cited by3WOSBibtex

Cutaneous tissue damage induces long-lasting nociceptive sensitization and regulation of cellular stress- and nerve injury-associated genes in sensory neurons.

Kristofer K. Rau,Caitlin E. Hill,Benjamin J. Harrison,Gayathri Venkat,Heidi M. Koenig, Sarah B. Cook,Alexander G. Rabchevsky,Bradley K. Taylor,Tsonwin Hai,Jeffrey C. Petruska

Experimental Neurology, (2016): 413-427

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ATF3 mediates inhibitory effects of ethanol on hepatic gluconeogenesis.

Wen-Wei Tsai,Shigenobu Matsumura,Weiyi Liu,Naomi G Phillips,Tim Sonntag,Ergeng Hao,Soon Lee,Tsonwin Hai,Marc Montminy

Proceedings of the National Academy of Sciences of the United States of America, no. 9 (2015): 2699-2704

Cited by5WOSBibtex

Efficient CRISPR/Cas9-mediated biallelic gene disruption and site-specific knockin after rapid selection of highly active sgRNAs in pigs.

Xuejing Wang, Jiafeng Zhou,C Cao, Jing Huang,Tsonwin Hai, Yue Wang, Qi Zheng, Hongjiang Zhang, Genji Qin, Xudong Miao,H Wang, Shiping Cao

Scientific Reports, (2015)

Cited by54Bibtex

ATF3-dependent cross-talk between cardiomyocytes and macrophages promotes cardiac maladaptive remodeling

Lilach Koren,Dror Alishekevitz,Ofer Elhanani,Alexsander Nevelsky,Tsonwin Hai,Izhak Kehat,Yuval Shaked,Ami Aronheim

International journal of cardiology, (2015)

Cited by7WOSBibtex

Islet Brain 1 Protects Insulin Producing Cells against Lipotoxicity.

S Brajkovic,M Ferdaoussi,Valerie Pawlowski,Helene Ezanno,Valerie Plaisance,Erik Zmuda,Tsonwin Hai,Jeansebastien Annicotte,Gerard Waeber,Amar Abderrahmani

Experimental Diabetes Research, (2015)

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Loss of ATF3 promotes hormone-induced prostate carcinogenesis and the emergence of CK5(+)CK8(+) epithelial cells.

Z Wang,J Kim,Y Teng,H-F Ding,J Zhang,T Hai,J K Cowell,C Yan

Oncogene, (2015)

Cited by2WOSBibtex

The Roles of ATF3, an Adaptive-Response Gene, in High-Fat-Diet-Induced Diabetes and Pancreatic β-Cell Dysfunction

Erik Zmuda,Ling Qi,Michael X Zhu,Raghavendra G Mirmira,Marc Montminy,Tsonwin Hai

The Journal of Clinical Endocrinology and Metabolism, (2013)

Cited by45Bibtex

Correction: Adult Cardiac Expression of the Activating Transcription Factor 3, ATF3, Promotes Ventricular Hypertrophy.

Lilach Koren, Ofer Elhanani, Izhak Kehat,Tsonwin Hai,Ami Aronheim

PloS one, no. 9 (2013)

WOSBibtex

感染症ROS誘導性ATF3は、敗血症に関連する免疫抑制の際に二次感染を起こしやすくする

Wolfram Hoetzenecker,Bernd Echtenacher,Emmanuella Guenova,Konrad Hoetzenecker,Florian Woelbing,Jurgen Bruck,Anna Teske,Nadejda Valtcheva,Kerstin Fuchs,Manfred Kneilling,Jihyeon Park, Kyuhan Kim

Nature Medicine, (2012)

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ROS-induced ATF3 causes susceptibility to secondary infections during sepsis-associated immunosuppression

Wolfram Hoetzenecker,Bernd Echtenacher,Emmanuella Guenova,Konrad Hoetzenecker,Florian Woelbing,Jurgen Bruck,Anna Teske,Nadejda Valtcheva,Kerstin Fuchs,Manfred Kneilling,Jihyeon Park,Kyuwon Kim

Nature Medicine, (2012)

Cited by63Bibtex

ATF3 Activating Transcription Factor 3

Tsonwin Hai, Johnna Dominick, Kun Huang

(2012)

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Abstract 909: Activation of NF-κB and its downstream targets play a key role in the dramatic induction of hepatocarcinogenesis in metallothionein null mice

Bo Wang,Stefan Costinean,Wendy L Frankel,Anna Bratasz,Periannan Kuppusamy,Tsonwin Hai,Sarmila Majumder,Samson T Jacob,Kalpana Ghoshal, Thomas Kaffenberger,Satavisha Roy

Cancer Research, (2011)

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Chapter Eleven - Immunohistochemical Detection of Activating Transcription Factor 3, a Hub of the Cellular Adaptive–Response Network

Tsonwin Hai,Swati Jalgaonkar, C C Wolford,Xin Yin

Methods in Enzymology, (2011)

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Immunohistochemical detection of activating transcription factor 3, a hub of the cellular adaptive-response network.

Tsonwin Hai,Swati Jalgaonkar,Christopher C Wolford,Xin Yin

Methods in enzymology, (2011): 175-194

Cited by6WOSEIBibtex

Angiotensin II signaling up-regulates the immediate early transcription factor ATF3 in the left but not the right atrium.

Tal Hasin,Ofer Elhanani,Zaid Abassi,Tsonwin Hai,Ami Aronheim

Basic research in cardiology, no. 2 (2011): 175-187

Cited by25WOSBibtex

Abstract 2843: Tumor macrophages utilize ATF3 to promote breast cancer metastasis

C C Wolford,Stephen Mcconoughey,Xin Yin,Anand Merchant,Marino Leon,Sandra A Otoole,Robert L Sutherland,M Ostrowski,Tsonwin Hai

Cancer Research, (2011)

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stabilization in human cancer cells Anoxic induction of ATF-4 via HIF-1 independent pathways of protein

Kurosh Ameri,Claire E Lewis,Martin Raida,Heidi Sowter,Tsonwin Hai,Adrian L Harris

(2010)

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ATF3 is activated in ventilator induced lung injury

Claudia Dos Santos,Ali Akram,Hussain Masoom,Bing Han,Jack J Haitsma,Claudia Peng,Yuexin Shan,Haibo Zhang,Mingyao Liu,Tsonwin Hai,Arthur S Slutsky

The FASEB Journal, (2010)

Cited by1Bibtex

Activating Transcription Factor 3 Protects Against Elastase-Induced Pulmonary Emphysema In Mice

Gopinath Packirisamy,Tsonwin Hai,Rubin M Tuder,Shiven Bhatt,Wayne Mitzner,Steve N Georas,Tirumalai Rangasamy

(2010)

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Adipocyte CREB promotes insulin resistance in obesity.

Ling Qi,Maziyar Saberi,Erik Zmuda,Yiguo Wang,Judith Altarejos,Xinmin Zhang,Renaud Dentin,Susie Hedrick,Gautam Bandyopadhyay,Tsonwin Hai,Jerry Olefsky,Marc Montminy

Cell metabolism, no. 3 (2009): 277-286

Cited by160WOSEIBibtex

ATF3 plays a protective role against toxicity by N-terminal fragment of mutant huntingtin in stable PC12 cell line.

Yideng Liang,Haibing Jiang,Tamara Ratovitski,Chunfa Jie,Masayuki Nakamura,Ricky R Hirschhorn,Xiaofang Wang,Wanli W Smith,Tsonwin Hai,Michelle A Poirier,Christopher A Ross

Brain research, (2009): 221-229

Cited by9WOSEIBibtex

The Repression of IRS2 Gene by ATF3, a Stress-Inducible Gene, Contributes to Pancreatic β-Cell Apoptosis

Dan Li,Xin Yin,Erik Zmuda,C C Wolford,X Dong,Morris F White,Tsonwin Hai

Diabetes, (2008)

Cited by38Bibtex

Initiation and execution of lipotoxic ER stress in pancreatic -cells

Daniel A. Cunha,Paul Hekerman,L. Ladriere,Angie Bazarra-Castro,Fernanda Ortis,Marion C. Wakeham,Fabrice Moore,Joanne Rasschaert,Alessandra K. Cardozo,Elisa Bellomo,Lutgart Overbergh,Chantal Mathieu

Journal of Cell Science, no. 14 (2008): 2308-2318

Cited by10Bibtex

Activating transcription factor 3 (ATF3) represses the expression of CCL4 in murine macrophages

Ciera H. Khuu,Roberto M. Barrozo,Tsonwin Hai,Steven L. Weinstein

Molecular Immunology, no. 7 (2007): 1598-1605

Cited by49EIWOSBibtex

The regulation of ATF3 gene expression by mitogen-activated protein kinases.

Dan Lu,Jingchun Chen,Tsonwin Hai

The Biochemical journal, no. 2 (2007): 559-567

Cited by148WOSBibtex

Induction of activating transcription factor 3 by anoxia is independent of p53 and the hypoxic HIF signalling pathway.

K Ameri,E M Hammond,C Culmsee,M Raida,D M Katschinski,R H Wenger,E Wagner,R J Davis,T Hai,N Denko,A L Harris

Oncogene, no. 2 (2007): 284-289

Cited by71WOSNATUREBibtex

HSF1 opens chromatin structure of IL-6 promoter to facilitate binding of an activator or a repressor

Sachiye Inouye,Mitsuaki Fujimoto, Tamami Nakamura,Eiichi Takaki, N Hayashida,Tsonwin Hai,Akira Nakai

Journal of Biological Chemistry, (2007)

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Negative regulation of TLR-signaling pathways by activating transcription factor-3.

Mark M Whitmore,Amaya Iparraguirre,Lindsey Kubelka,Wolfgang Weninger,Tsonwin Hai,Bryan R G Williams

Journal of immunology (Baltimore, Md. : 1950), no. 6 (2007): 3622-3630

Cited by176WOSBibtex

DepartmentofMolecularandCellularBiochemistry,OhioStateUniversity,Columbus,Ohio43210

Jeffrey S Huo,Richard C Mceachin,Tracy Xiao Cui,Nisha K Duggal,Tsonwin Hai,David J States,Jessica Schwartz

(2006)

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TRANSCRIPTION FACTORS | ATF

Tsonwin Hai, Dihong Lu, C C Wolford

(2006)

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Systems biology approaches identify ATF3 as a negative regulator of Toll-like receptor 4.

Mark Gilchrist,Vesteinn Thorsson,Bin Li,Alistair G Rust,Martin Korb,Jared C Roach,Kathleen Kennedy,Tsonwin Hai, Hamid Bolouri,Alan Aderem

Nature, no. 7090 (2006): 173-178

Cited by409WOSNATUREBibtex

Activating transcription factor 3, a stress sensor, activates p53 by blocking its ubiquitination.

Chunhong Yan,Dan Lu,Tsonwin Hai,Douglas D Boyd

The EMBO journal, no. 13 (2005): 2425-2435

Cited by124WOSBibtex

endothelial hypoxic stress protein Identification of protein disulfide isomerase as an

Krista K Graven,Christopher Molvar,Brian D Klahn,Roy Bicknell,D C Sullivan,Lukasz Huminiecki,John W Moore,Joseph J Boyle,Richard Poulsom, Daniel Creamer, Jonathan N Barker, K Ameri

(2005)

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Activating transcription factor 3 (ATF3) stabilizes p53 in genotoxic response

Chunhong Yan,Tsonwin Hai, Douglas Boyd

Cancer Research, (2005): 862-862

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Anoxic induction of ATF-4 through HIF-1-independent pathways of protein stabilization in human cancer cells.

Kurosh Ameri,Claire E Lewis,Martin Raida,Heidi Sowter,Tsonwin Hai,Adrian L Harris

Blood, no. 5 (2004): 1876-1882

Cited by157WOSBibtex

Activating transcription factor 3 is integral to the eukaryotic initiation factor 2 kinase stress response.

Hao-Yuan Jiang,Sheree A Wek,Barbara C McGrath,Dan Lu,Tsonwin Hai,Heather P Harding,Xiaozhong Wang,David Ron,Douglas R Cavener,Ronald C Wek

Molecular and cellular biology, no. 3 (2004): 1365-1377

Cited by450WOSBibtex

Role for Activating Transcription Factor 3 in Stress-Induced -Cell Apoptosis

Matthew G. Hartman,Dan Lu,Mi-Lyang Kim,Gary J. Kociba,Tala Shukri,Jean Buteau,Xiaozhong Wang,Wendy L. Frankel,Denis Guttridge,Marc Prentki,Shane T. Grey,David Ron

Molecular and Cellular Biology, no. 13 (2004): 5721-5732

Cited by40Bibtex

ATF4 Degradation Relies on a Phosphorylation-Dependent Interaction with the SCF TrCP Ubiquitin Ligase

IRINA LASSOT,EMMANUEL SEGERAL,CLARISSE BERLIOZ-TORRENT,HERVE DURAND,LIONEL GROUSSIN,TSONWIN HAI,RICHARD BENAROUS,FLORENCE MARGOTTIN-GOGUET

Molecular and Cellular Biology, no. 6 (2001): 2192-2202

Cited by23Bibtex

The roles of ATF3 in glucose homeostasis. A transgenic mouse model with liver dysfunction and defects in endocrine pancreas.

A E Allen-Jennings,M G Hartman,G J Kociba,T Hai

The Journal of biological chemistry, no. 31 (2001): 29507-29514

Cited by70WOSBibtex

Transgenic mice with cardiac-specific expression of activating transcription factor 3, a stress-inducible gene, have conduction abnormalities and contractile dysfunction.

Y Okamoto,A Chaves,J Chen,R Kelley,K Jones,H G Weed,K L Gardner,L Gangi,M Yamaguchi,W Klomkleaw,T Nakayama,R L Hamlin

The American journal of pathology, no. 2 (2001): 639-650

Cited by91WOSEIBibtex

The molecular biology and nomenclature of the activating transcription factor/cAMP responsive element binding family of transcription factors: activating transcription factor proteins and homeostasis.

T Hai,M G Hartman

Gene, no. 1 (2001): 1-11

Cited by581WOSBibtex

A TRANSGENIC MOUSE MODEL WITH LIVER DYSFUNCTION AND DEFECTS IN ENDOCRINE PANCREAS

Amy E. Allen-Jennings,Matthew G. Hartman,Gary J. Kociba,Tsonwin Hai

(2001)

Cited by22Bibtex

Transcriptional Autorepression of the Stress-inducible GeneATF3

Curt D Wolfgang,Guosheng Liang,Yoshichika Okamoto,Amy E Allen,Tsonwin Hai

Journal of Biological Chemistry, (2000)

Cited by70Bibtex

Transcriptional Autorepression of the Stress-inducible Gene ATF3

Wolfgang C D,Liang G,Okamoto Y,Allen A E,Hai T

The Journal of biological chemistry, no. 22 (2000): 16865-16870

Cited by7WOSBibtex

Transcriptional autorepression of the stress-inducible gene Activating Transcription Factor 3

Curt D Wolfgang,Guosheng Liang,Yoshichika Okamoto, Amy E Allen,Tsonwin Hai

Journal of Biological Chemistry, (2000)

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Epidermal growth factor induction of the c-jun promoter by a Rac pathway.

N Clarke,N Arenzana,T Hai,A Minden,R Prywes

Molecular and cellular biology, no. 2 (1998): 1065-1073

Cited by94WOSBibtex

ATF3: A transcription repressor involved in stress responses

Curt D. Wolfgang, A. E. Alien,Guosheng Liang, H. Vaessin,Tsonwin Hai

The FASEB Journal, no. 9 (1997)

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Characterization of Human Activating Transcription Factor 4, a Transcriptional Activator That Interacts with Multiple Domains of cAMP-responsive Element-binding Protein (CREB)-binding Protein (CBP)

Guosheng Liang,Tsonwin Hai

Journal of Biological Chemistry, no. 38 (1997): 24088-24095

Cited by97Bibtex

Cyclic AMP-Independent ATF Family MembersInteract with NF-KBandFunction intheActivation oftheE-Selectin Promoter inResponse toCytokines

WIWEKA KASZUBSKA,ROB HOOFT vAN HUIJSDUIJNEN,PAOLA GHERSA,ANNE-MARIE DERAEMY-SCHENK,BENJAMIN P. C. CHEN,TSONWIN HAI,JOHN F. DELAMARTER

(1993)

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Analysis of the role of the transcription factor ATF in the assembly of a functional preinitiation complex

Tsonwin Hai,Masami Horikoshi,Robert G. Roeder,Michael R. Green

Cell, no. 7 (1988): 1043-1051

Cited by103EIWOSBibtex

Transcription factor ATF interacts with the TATA factor to facilitate establishment of a preinitiation complex.

M Horikoshi,T Hai,Y S Lin,M R Green,R G Roeder

Cell, no. 7 (1988): 1033-1042

Cited by254WOSEIBibtex

Profiles of Growth Hormone (GH)-regulated Genes Reveal Time-dependent Responses and Identify a Mechanism for Regulation of Activating Transcription

Jeffrey S. Huo,Richard C. McEachin,Tracy Xiao Cui,Nisha K. Duggal,Tsonwin Hai,David J. States,Jessica Schwartz

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and sleep homeostasis in the fruit fly

Naoya Sawamura,Tetsuya Ando,Yasushi Maruyama,Masahiro Fujimuro,Hiroaki Mochizuki,Ken Honjo,Masami Shimoda,Hirofumi Toda,Takako Sawamura-Yamamoto,Lauren A Makuch,Akiko Hayashi,Koko Ishizuka

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The ATF Transcription Factors in Cellular Adaptive Responses

Tsonwin Hai

Cited by3Bibtex

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