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职业迁徙
个人简介
He is currently a Professor of Molecular & Medical Pharmacology, who also holds joint memberships in the California NanoSystems Institute, Crump Institute for Molecular Imaging, and Jonsson Comprehensive Cancer Center on the UCLA campus. His research interest falls in developing nanotechnology-enabled diagnostic and therapeutic solutions for cancer and genetic diseases.
Specialties: Synthetic Chemistry
Microfluidic Engineering
In Vitro Molecular Diagnostics
Molecular Imaging
Nanotechnology
Biotechnology
Dr. Tseng’s research team has been working to develop in vitro molecular diagnostics (IVMD) technologies for applications in the fields of cancer and prenatal diagnosis. With continuous support from National Cancer Institute via R21, R33, RO1, UO1, PO1, U54, and SBIR funding mechanisms, the team has built a series of nanotechnology- and microfluidics-enabled IVMD technologies. More specifically, their nanomaterials-embedded diagnostic platforms (a.k.a., NanoVelcro Assays and NanoVilli Assays) offer a unique liquid biopsy method for detection, enrichment, and characterization of circulating tumor cells (CTCs), circulating fetal nucleated cells (CFNCs), and EVs in peripheral blood. In the meantime, Dr. Tseng established an extensive collaboration network with Oncology and Maternal-Fetal Medicine programs at UCLA, Cedars Sinai Medical Center, and several major medical institutions overseas to validate and translate their new IVMD technologies into the clinical setting. In parallel, Dr. Tseng’s research team has developed a self-assembly synthetic approach for the preparation of Supramolecular Nanoparticle (SMNP) vectors that hold potential for diagnostic, therapeutic, and theranostic applications in cancer and genetic diseases. Recently, the team has been exploiting the use of SMNP vectors for co-delivery of CRISPR/Cas9 genome editing system (including Cas9 protein, single-guide RNA, and donor DNA plasmid) in order to precisely modify the nucleotide sequence for treating genetic diseases, for example, beta hemoglobinopathies and X-linked juvenile retinoschisis.
Specialties: Synthetic Chemistry
Microfluidic Engineering
In Vitro Molecular Diagnostics
Molecular Imaging
Nanotechnology
Biotechnology
Dr. Tseng’s research team has been working to develop in vitro molecular diagnostics (IVMD) technologies for applications in the fields of cancer and prenatal diagnosis. With continuous support from National Cancer Institute via R21, R33, RO1, UO1, PO1, U54, and SBIR funding mechanisms, the team has built a series of nanotechnology- and microfluidics-enabled IVMD technologies. More specifically, their nanomaterials-embedded diagnostic platforms (a.k.a., NanoVelcro Assays and NanoVilli Assays) offer a unique liquid biopsy method for detection, enrichment, and characterization of circulating tumor cells (CTCs), circulating fetal nucleated cells (CFNCs), and EVs in peripheral blood. In the meantime, Dr. Tseng established an extensive collaboration network with Oncology and Maternal-Fetal Medicine programs at UCLA, Cedars Sinai Medical Center, and several major medical institutions overseas to validate and translate their new IVMD technologies into the clinical setting. In parallel, Dr. Tseng’s research team has developed a self-assembly synthetic approach for the preparation of Supramolecular Nanoparticle (SMNP) vectors that hold potential for diagnostic, therapeutic, and theranostic applications in cancer and genetic diseases. Recently, the team has been exploiting the use of SMNP vectors for co-delivery of CRISPR/Cas9 genome editing system (including Cas9 protein, single-guide RNA, and donor DNA plasmid) in order to precisely modify the nucleotide sequence for treating genetic diseases, for example, beta hemoglobinopathies and X-linked juvenile retinoschisis.
研究兴趣
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Nature communicationsno. 1 (2024): 3693-3693
HEPATOLOGY COMMUNICATIONSno. 5 (2024)
BIOLOGY OF REPRODUCTION (2024)
Placenta (2024): 8-21
JOURNAL OF CLINICAL ONCOLOGYno. 16 (2023): e17034-e17034
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Jing Sun,Michael D. Masterman-Smith, Nicholas A. Graham,Jing Jiao,Jack Mottahedeh,Dan R. Laks,Minori Ohashi, Jason DeJesus,Ken-ichiro Kamei,Ki-Bum Lee,Hao Wang, Zeta T.F. Yu,
crossref(2023)
LABORATORY INVESTIGATIONno. 3 (2023): S1568-S1569
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