基本信息
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职业迁徙
个人简介
Research Interests
1. Embryonic stem cells and their cardiac derivatives:
a. Mechanisms for maintaining the self-renewal and pluripotent characteristics of embryonic stem cells.
b. Mechanisms controlling the cardiac differentiation of embryonic stem cells.
c. Mechanisms of automaticity of embryonic stem cell-derived cardiomyocytes.
2. Ion channels and cardiovascular physiology.
3. Adult stem cells and cancer stem cells.
Representative Publications
Qi Z, Wong CK, Suen CH, Wang J, Long C, Sauer H, Yao XQ, Tsang SY (2015). TRPC3 regulates the automaticity of embryonic stem cell-derived cardiomyocytes. Int J Cardiol. Accepted
Lo IC, Chan HC, Qi Z, Ng KL, So C and Tsang SY (2015) TRPV3 channel negatively regulates cell cycle progression and safeguards the pluripotency of embryonic stem cells. J Cell Physiol. Epub ahead of print.
Qi Y, Qi Z, Li Z, Wong CK, So C, Lo IC, Huang Y, Yao XQ, and Tsang SY (2015). Role of TRPV1 in the differentiation of mouse embryonic stem cells into cardiomyocytes. PLoS One. 10(7):e0133211.
Law SK, Leung CSL, Yau KL, Tse CL, Wong CK, Leung FP, Huang Y, Sauer H and Tsang SY (2013) Regulation of multiple transcription factors by reactive oxygen species and effects of pro-inflammatory cytokines released during myocardial infarction on cardiac differentiation of embryonic stem cells. Int J of Cardiol.168:3458-72.
Yang C, Chen ZY, Wong SL, Liu J, Liang YT, Lau CW, Lee HK, Huang Y, and Tsang SY (2012) Beta-sitosterol oxidation products attenuated vasorelaxation by increasing reactive oxygen species and cyclooxygenase-2. Cardiovascular Res.97:520-32.
Wong CK, So WY, Law SK, Leung FP, Yau KL, Yao X, Huang Y, Li X, Tsang SY (2012) Estrogen controls embryonic stem cell proliferation via store-operated calcium entry & the nuclear factor of activated T-cells (NFAT). J Cell Physiol. 227:2519-30. (this article was selected to appear in the highlighted section)
Peng LH, Tsang SY, Tabata Y, Gao JQ (2011) Genetically-manipulated adult stem cells as therapeutic agents and gene delivery vehicle for wound repair and regeneration. J Control Release. Epub ahead of print.
Lau YT, Wong CK, Luo J, Leung LH, Tsang PF, Bian ZX, and Tsang SY (2011) Effects of hyperpolarization-activated cyclic nucleotide-gated (HCN) channel blockers on the proliferation and cell cycle progression of embryonic stem cells. Pflugers Archiv Eur J Physiol.461(1):191-202.
Ng SY, Wong CK, and Tsang SY (2010) Differential expression of genes in atrial and ventricular myocytes: insights into the application of embryonic stem cell-derived cardiomyocytes for future therapies. Am J Physiol Cell Physiol. 299:C1234-12.
Ng SY, Chin CH, Lau YT, Luo J, Wong CK, Bian ZX, and Tsang SY (2010) Role of voltage-gated potassium channels in the fate determination of embryonic stem cells. J Cell Physiol. 224:165-77. (this article was selected to appear in the highlighted section)
Moore JC*, Tsang SY*, Rushing SN, Lin D, Chan CW, and Li RA (2008) Functional consequences of overexpressing the gap junction Cx43 in the cardiogenic potential of pluripotent human embryonic stem cells. Biochem Biophys Res Commun. 377:46-51. (*co-first authorship)
Tsang SY, Moore JC, Huizen RV, Chan CWY, and Li RA (2007) Ectopic expression of systemic RNA interference defective protein (SID-1) in embryonic stem cells. Biochem Biophys Res Commun. 357:480-6.
Tsang SY*, Yao XQ, Chan HY, Chan FL, Leung CSL, Yung LM, Au CL, Chen ZY, Laher I, Huang Y (2007) Tamoxifen and estrogen attenuate enhanced vascular reactivity induced by estrogen deficiency in rat carotid arteries. Biochem Pharmacol. 73:1330-9. (*corresponding author)
Xue T, Cho HC, Akar FG, Tsang SY, Jones SP, Marbán E, Tomaselli GF and Li RA (2005) Functional integration of electrically-active cardiac derivatives from genetically-engineered human embryonic stem cells with quiescent recipient ventricular cardiomyocytes: Insights into the development of cell-based pacemakers. Circulation111:11-20.
Tsang SY, Lesso H and Li RA (2004) Dissecting the structural and functional roles of the S3-S4 linker of pacemaker (HCN) channels by systematic length alterations. J Biol Chem279:43752-9.
Tsang SY, Yao XQ, Chan FL, Wong CM, Chen ZY, Laher I and Huang Y (2004) Estrogen and tamoxifen modulate cerebrovascular tone in ovariectomized female rats. Hypertension44:1-5.
Tsang SY, Yao XQ, Essin K, Wong CM, Chan FL, Gollasch M and Huang Y (2004) Raloxifene relaxes rat cerebral arteries in vitro and inhibits L-type voltage-sensitive Ca2+ channels. Stroke35:1709-14.
研究兴趣
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Acta biomaterialia (2021): 582-592
Ecotoxicology and environmental safety (2020): 110827-110827
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