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How does the cell ensure transmission of an exact complement of chromosomes each cell division? How does this process go awry in cancer cells? These are questions of interest to our lab. We use a variety of techniques from single-molecule biophysical approaches to biochemistry, genetics and microscopy to explore the regulation and assembly of the machinery that ensures each daughter cell receives a full set of chromosomes every cell division.
Chromosomes are segregated to daughter cells by a microtubule-based molecular machine, the mitotic spindle. The spindle has two poles, each one carrying an exact complement of chromosomes to each daughter cell. Spindle morphogenesis requires spatially controlled microtubule nucleation. The proteins required for nucleation are known, but they are surprisingly inactive in isolated form. We are studying how these proteins are activated to nucleate microtubules during spindle formation and how their activation is regulated.
How does the cell ensure transmission of an exact complement of chromosomes each cell division? How does this process go awry in cancer cells? These are questions of interest to our lab. We use a variety of techniques from single-molecule biophysical approaches to biochemistry, genetics and microscopy to explore the regulation and assembly of the machinery that ensures each daughter cell receives a full set of chromosomes every cell division.
Chromosomes are segregated to daughter cells by a microtubule-based molecular machine, the mitotic spindle. The spindle has two poles, each one carrying an exact complement of chromosomes to each daughter cell. Spindle morphogenesis requires spatially controlled microtubule nucleation. The proteins required for nucleation are known, but they are surprisingly inactive in isolated form. We are studying how these proteins are activated to nucleate microtubules during spindle formation and how their activation is regulated.
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bioRxiv : the preprint server for biology (2024)
The EMBO journalno. 15 (2023): e113565-e113565
biorxiv(2022)
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