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职业迁徙
个人简介
RESEARCH FOCUS
1. Primary immonodeficiencies (genetics and immunology)
2. Pathogenesis of virus infections
3. Viral CNS infections
Identification of the genetic and immunological basis of severe infectious diseases
In recent years, it has emerged that mutations in genes encoding proteins of innate or cell-intrinsic immunity may underlie rare primary immunodeficiencies in humans. Within the framework of my research program, we are aiming at the identification and functional immunological characterization of novel genetic defects predisposing to severe viral infections, including herpes encephalitis (brian infection), meningitis, poliomyelitis, and severe influenza. This requires studies on basic genetics, cell biology, and immunology on the one hand, and the identification of patients with a rare but severe infectious phenotype, who may directly benefit from our findings in terms of choosing optimal prophylactic and treatment strategies on the other hand. The scope is therefore truly translational medical research focusing on very rare diseases, from which we can learn basic infection immunology and at the same time use this knowledge to inform decision making on diagnosis, prophylaxis, and treatment of these severe infectious diseases.
1. Primary immonodeficiencies (genetics and immunology)
2. Pathogenesis of virus infections
3. Viral CNS infections
Identification of the genetic and immunological basis of severe infectious diseases
In recent years, it has emerged that mutations in genes encoding proteins of innate or cell-intrinsic immunity may underlie rare primary immunodeficiencies in humans. Within the framework of my research program, we are aiming at the identification and functional immunological characterization of novel genetic defects predisposing to severe viral infections, including herpes encephalitis (brian infection), meningitis, poliomyelitis, and severe influenza. This requires studies on basic genetics, cell biology, and immunology on the one hand, and the identification of patients with a rare but severe infectious phenotype, who may directly benefit from our findings in terms of choosing optimal prophylactic and treatment strategies on the other hand. The scope is therefore truly translational medical research focusing on very rare diseases, from which we can learn basic infection immunology and at the same time use this knowledge to inform decision making on diagnosis, prophylaxis, and treatment of these severe infectious diseases.
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EUROPEAN JOURNAL OF NEUROLOGYno. 1 (2024)
Michelle Mølgaard Thomsen,Morten Kelder Skouboe,Michelle Møhlenberg, Jian Zhao,Kerstin de Keukeleere, Johanna Laura Heinz,Marvin Werner,Anne Kruse Hollensen, Jonas Lønskov, Ian Nielsen,Madalina Elena Carter-Timofte,Baocun Zhang,
Research Square (Research Square)no. 2 (2024): 1-19
Martti Vanker,Karita Särekannu,Arnaud Fekkar,Sofie Eg Jørgensen,Liis Haljasmägi, Anne Kallaste,Kalle Kisand, Margus Lember,Pärt Peterson,Madhvi Menon,Tracy Hussell,Sean Knight,
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Researchno. 9 (2023): 379-393
Pathogens (Basel, Switzerland)no. 2 (2023): 310-310
Kristian Assing,Sofie E. Jørgensen,Katrine S. Sandgaard,Kerstin De Keukeleere, Marie B.-Hansen,Mikkel S. Petersen,Ulla B. Hartling, Thanis M. K.-de Vaal,Christian Nielsen,Marianne A. Jakobsen,Eleanor Watt,Stuart Adams,
Journal of clinical immunologyno. 8 (2023): 1927-1940
The Lancet. Infectious diseasesno. 4 (2023): E160-E165
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