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Dr. Tomer’s research program focuses on the immunogenetic, epigenetic, and environmental mechanisms underlying thyroid autoimmunity, and type 1 diabetes, and on targeting these mechanisms in order to develop novel therapies. His group made several discoveries including identifying new genes and mechanisms underlying the strong association between type 1 diabetes and autoimmune thyroiditis; demonstrating that CD40 and thyroglobulin are major susceptibility genes for thyroid autoimmunity; identifying a unique amino acid variant in the peptide binding pocket of HLA-DR that is key for the development of thyroid autoimmunity; dissecting the epigenetic mechanisms by which polymorphisms in the thyroglobulin and TSHR genes interact with environmental agents (e.g. viruses) to trigger thyroid autoimmunity; demonstrating that the hepatitis C virus can trigger autoimmune thyroiditis by directly infecting thyroid cells; and identifying a novel small molecule that can block antigen presentation in autoimmune thyroiditis.
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Current protocolsno. 3 (2024): e938-e938
Swagatika Paul,Shireen Sarraf, Ki Hong Nam, Nicole DeRoor, Sahitya Biswas,Tomer Yaron,Lewis Cantley,Alban Ordureau,Alicia Pickrell
Journal of Biological Chemistryno. 3 (2023): 104359-S744
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Journal of the Endocrine Societyno. Supplement_1 (2023)
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Thyroid : official journal of the American Thyroid Associationno. 4 (2023): 492-500
Journal of the Endocrine Societyno. Supplement_1 (2022)
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