基本信息
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职业迁徙
个人简介
My Research
KEYWORDS
cancer, computational biology, epidemiology, genomics
SUMMARY
The primary interest of my laboratory is focused on the identification of the genetic basis of cancer susceptibility. A key question in these efforts is how the germline genetic events contributing to predisposition of human cancers interact mutually in particular molecular pathways or in concert with the environmental exposures. Specifically, our ongoing studies aim at identification of the genetic variants conferring an increased risk to common cancers, such as breast, colon, prostate cancers or lymphoma, focusing on the relevant molecular pathways. These studies combine the genome-wide association analysis (GWAS), high-throughput genotyping and most recently the next-generation sequencing in large case/control populations. The significant aspect of my current and future research is an integration of the information from somatic genetics in tumors to complement the germline findings. We believe that such integration of biological data will be beneficial not only for improved prevention strategies but most importantly for the future development of the targeted personalized therapies.
KEYWORDS
cancer, computational biology, epidemiology, genomics
SUMMARY
The primary interest of my laboratory is focused on the identification of the genetic basis of cancer susceptibility. A key question in these efforts is how the germline genetic events contributing to predisposition of human cancers interact mutually in particular molecular pathways or in concert with the environmental exposures. Specifically, our ongoing studies aim at identification of the genetic variants conferring an increased risk to common cancers, such as breast, colon, prostate cancers or lymphoma, focusing on the relevant molecular pathways. These studies combine the genome-wide association analysis (GWAS), high-throughput genotyping and most recently the next-generation sequencing in large case/control populations. The significant aspect of my current and future research is an integration of the information from somatic genetics in tumors to complement the germline findings. We believe that such integration of biological data will be beneficial not only for improved prevention strategies but most importantly for the future development of the targeted personalized therapies.
研究兴趣
论文共 170 篇作者统计合作学者相似作者
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Milad Ibrahim,Irineu Illa-Bochaca, Faisal Fa'ak,Kelsey R. Monson,Robert Ferguson,Chen Lyu,Eleazar Vega-Saenz de Miera,Paul Johannet,Margaret Chou, Justin Mastroianni,Farbod Darvishian,Tomas Kirchhoff,
CANCERSno. 1 (2024): 18
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Manny D. Bacolod,Gunter S. Schemmann,Shuang Wang, Richard Shattock,Sarah F. Giardina,Zhaoshi Zeng,Jinru Shia, Robert F. Stengel,Norman Gerry, Josephine Hoh,Tomas Kirchhoff,Bert Gold,
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JOURNAL OF CLINICAL ONCOLOGYno. 16 (2023): e21571-e21571
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