基本信息
浏览量:38
职业迁徙
个人简介
Research Question
Molecular mechanisms of stem cell quiescence and activation
Adult stem cells have the unique ability to produce differentiated daughter cells as well as replenish the stem pool through the process of self-renewal. In the absence of stimulus, subsets of mammalian adult stem cells can reside in the quiescent state for prolonged periods of time. Importantly, disruption of quiescence was shown to result in the depletion of the stem cell pool. Satellite cells are adult muscle stem cells that are primarily quiescent in resting muscle and that represent an excellent model to study stem cell quiescence. The main areas of interest of the laboratory are to specify the molecular pathways that control stem cell quiescence and stem cell-mediated tissue regeneration. Using both in vitro and in vivo approaches, we are also interested in getting a better understanding of adult stem cell function in the context of tissue regeneration, disease and aging.
Molecular mechanisms of stem cell quiescence and activation
Adult stem cells have the unique ability to produce differentiated daughter cells as well as replenish the stem pool through the process of self-renewal. In the absence of stimulus, subsets of mammalian adult stem cells can reside in the quiescent state for prolonged periods of time. Importantly, disruption of quiescence was shown to result in the depletion of the stem cell pool. Satellite cells are adult muscle stem cells that are primarily quiescent in resting muscle and that represent an excellent model to study stem cell quiescence. The main areas of interest of the laboratory are to specify the molecular pathways that control stem cell quiescence and stem cell-mediated tissue regeneration. Using both in vitro and in vivo approaches, we are also interested in getting a better understanding of adult stem cell function in the context of tissue regeneration, disease and aging.
研究兴趣
论文共 54 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Pauline Garcia,William Jarassier,Caroline Brun,Lorenzo Giordani,Fany Agostini, Wai Hing Kung,Cecile Peccate, Jade Ravent, Sidy Fall, Valentin Petit,Tom Cheung,Slimane Ait-Si-Ali,
bioRxiv (Cold Spring Harbor Laboratory) (2024)
Chunye Liu, Yishu Xu, Guowei Yang,Yu Tao,Jiali Chang,Shihui Wang,Tom H. Cheung,Jianfeng Chen,Yi Arial Zeng
CELL STEM CELLno. 1 (2024): 89-105.e6
Methods in molecular biology (Clifton, N.J.) (2023): 369-395
Methods in molecular biology (Clifton, N.J.) (2023): 445-452
Xuesong Feng,A Hongjun Wang,Aster H Juan,Kyung Dae Ko,Kan Jiang, Giulia Riparini,Veronica Ciuffoli, Aissah Kaba, Christopher Lopez,Faiza Naz,Michal Jarnik, Elizabeth Aliberti,
Developmental cellno. 12 (2023): 1052-1070.e10
STAR PROTOCOLSno. 4 (2023): 102750-102750
Wenshu Zeng,Wenxin Zhang,Erin H Y Tse,Jing Liu,Anqi Dong, Kim S W Lam, Shaoyuan Luan, Wai Hing Kung, Tsz Ching Chan,Tom H Cheung
Developmental cellno. 15 (2023): 1383-1398.e6
Qing Cissy Yu, Ajun Geng,Christopher B Preusch,Yujie Chen,Guangdun Peng, Yishu Xu,Yingying Jia,Yi Miao,Huaqing Xue,Dong Gao,Lan Bao,Weijun Pan,
Social Science Research Networkno. 8 (2022): 111694-111694
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn