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Main achievements: Scientific contribution to the field of complement, with emphasize on 1) Development of a principally new methodology for detection of activation of the complement system, led to a paradigm shift in methods used for complement research. The design of the mAb-based neoepitope TCC assay (PhD 1985) was crucial. Using this new platform it was shown that the complement system is not only beneficial in the host defense, but when over-activated turned to be the body’s worst enemy, like in sepsis. Here, this immune over-activation leads to the death of a patient, and not the bacteria per se. 2) Further, the research characterized the important link between the complement system and another innate immune branch – the Toll-like receptors, and lead to the hypothesis of the dual blocked of complement (C3/C5) and the CD14 TLR co-receptor. Blockade of these two systems was a cutting edge discovery, showing that the inflammation contributing to a number of diseases, including infection and sepsis, trauma and cardiovascular diseases could be substantially reduced and the conditions improved in several animal models. 3) Currently, the research focus is on the implementation of these drugs and strategies to treat patients in the clinic with the aim of reducing morbidity and mortality.
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biorxiv(2023)
Beatrice Fageräng,Corinna Lau, Karin Ekholt Mc Adam,Camilla Schjalm,Peter Garred,Per Nilsson,Tom Eirik Mollnes
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