Todd A. Fehniger

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Bio

My basic science research program focuses on benign and malignant lymphocyte biology, which informs a translational immunotherapy effort to develop novel treatments for cancer patients.

Basic and Translational Natural killer (NK) Cell Biology: The long term goals of this research program are to better understand the cellular networks and molecular programs that regulate natural killer (NK) cell development and activation, and translate basic NK cell biology into novel treatments for patients with cancer.

Research Interests

Papers共 326 篇Author StatisticsCo-AuthorSimilar Experts

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ACLY Promotes NK Cell Effector Function by Regulating Glycolysis and Histone Acetylation

Hyogon Sohn,Ana Kolicheski, Jennifer Laurent,Jennifer Tran, Yongjun Wang, Kelly Gan, Joshua M Tobin,Nermina Saucier,Todd A Fehniger, Jacqueline Payton,Megan A Cooper

biorxiv（2025）

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First-in-Human Phase I Study of a CD16A Bispecific Innate Cell Engager, AFM24, Targeting EGFR-Expressing Solid Tumors

Anthony El-Khoueiry,Omar Saavedra, Jacob Thomas, Claire Livings,Elena Garralda,Gabriele Hintzen,Laura Kohlhas, Dessislava Vanosmael,Joachim Koch,Erich Rajkovic,Paulien Ravenstijn,Paolo Nuciforo,Todd A Fehniger,Mark Foster,Melissa M Berrien-Elliott,Susanne Wingert, Sina Stäble,Daniela Morales-Espinosa, Delcia Rivas,Michael Emig,Juanita Lopez

Clinical cancer research an official journal of the American Association for Cancer Research（2025）

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Memory-like NK Cell Differentiation, Inhibitory NKG2A Blockade, and Improved Recognition Via Antibody or CAR Engineering Combine to Enhance NK Cell Attack Against Multiple Myeloma

Alice Y Zhou,Nancy D Marin, Sadia Afrin,Pamela Wong,Jennifer Tran,Miriam T Jacobs,Michelle Becker-Hapak,Lynne Marsala,Mark Foster,Jennifer A Foltz,Carly C Neal,David A Russler-Germain, Lyra Morina, Yeeun Paik,Celia C Cubitt,Timothy Schappe,Patrick Pence,Ethan McClain,Sarah Kelley, Julie Fortier, Mark Fiala,Michael Slade, Mark Schroeder,Keith Stockerl-Goldstein,Ravi Vij,Feng Gao,Melissa M Berrien-Elliott,Todd A Fehniger

Journal of immunology (Baltimore, Md 1950)no. 1 (2025): 1-11

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Stroma-derived Dickkopf-1 Contributes to the Suppression of NK Cell Cytotoxicity in Breast Cancer

Seunghyun Lee,Biancamaria Ricci,Jennifer Tran,Emily Eul,Jiayu Ye,Qihao Ren,David Clever, Julia Wang,Pamela Wong, Michael S. Haas,Sheila A. Stewart,Cynthia X. Ma,Todd A. Fehniger,Roberta Faccio

Nature Communications（2025）

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Figure S6 from High-Dimensional Analyses Reveal IL15 Enhances Activation of Sipuleucel-T Lymphocyte Subsets and Reverses Immunoresistance

Muhammad A. Saeed, Bo Peng,Kevin Kim,Kavita Rawat,Lindsey M. Kuehm,Zoe R. Siegel,Ariel Borkowski,Nabih Habib,Brian Van Tine,Nadeem Sheikh,Vu Tuyen,Daniel L.J. Thorek,Todd A. Fehniger,Russell K. Pachynski

crossref（2024）

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Fat Matters for Natural Killer Cell Activity

Pamela Wong,Todd A. Fehniger

Nature Immunologyno. 5 (2024): 728-730

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W-NK1 Choreographs Innate and Adaptive Immune Responses to Provide a Robust and Durable Anti-AML Response

Tom Leedom, Basia Muz,Kristann Magee,Jayakumar Vadakekolathu,Laura Arthur, Melissa Tran,Lena Luukkonen,Nitin Mahajan,Alexander Hamil,John Muth,Melissa M Berrien-Elliott,Todd A Fehniger,Sergio Rutella,Jan K Davidson-Moncada

Bloodno. Supplement 1 (2024): 916-916

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Comprehensive Characterization and Validation of the Tumor Microenvironment in Patients with Relapsed/Refractory Large B-Cell Lymphoma Identifies Subgroups with Greatest Benefit from CD19 CAR T-Cell Therapy

Xubin Li,Kartik Singhal,Qing Deng,Dai Chihara,David A Russler-Germain, Usama Hussein,Jennifer Ann Foltz,Jared Henderson,Ashley Wilson, Evelyn Schmidt,Imran A. Nizamuddin, Tommy Dinh,Ryan Sun, Akhil Kesaraju,Laura K. Hilton,David W. Scott,Francisco Vega,Christopher R. Flowers,Obi Griffith,Todd A Fehniger,Malachi Griffith,Michael R. Green

Bloodno. Supplement 1 (2024): 643-643

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A “prime and Expand” Strategy Using the Multifunctional Fusion Proteins to Generate Memory-Like NK Cells for Cell Therapy

Cancer Immunology Immunotherapyno. 9 (2024)

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Professor

Papers共 326 篇Author StatisticsCo-AuthorSimilar Experts