基本信息
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职业迁徙
个人简介
I seek to understand how mammalian cells process information and make decisions. This is a fundamental open
question as cells are controlled by multiple signaling pathways with tens of signaling proteins, second
messengers and chromatin modifiers connected to each other on time-scales of seconds to days by positive and
negative feedbacks. Understanding how signaling circuits control cell proliferation, migration and other outputs
is important for identifying optimal drug targets and to facilitate the development of combination therapies. Much
of my work is built on the premise that genetic and biochemical methods can be used to identify and characterize
components of signaling circuits, but that single-cell microscopy, live-cell signaling reporters, and rapid
perturbations are needed to understand the design principles of signaling circuits. My laboratory has pioneered
the development and use of molecular tools and quantitative microscopy methods to understand feedbackconnected signaling circuits and made key contributions to our understanding of the spatial and temporal control
of calcium, lipid second messenger, small GTPase, and protein kinase signaling processes. Our current research
identifies general control principles and specific mechanisms how cells integrate receptor, cell contact and stress
inputs to decide between quiescence, proliferation and senescence, how they switch metabolic states, and how
they trigger polarization and decide to move. We are investigating these signaling circuits by combining highresolution live-cell analysis of signal transduction and local chromatin activity with optogenetic perturbations,
single-cell RNAseq and computational modeling.
研究兴趣
论文共 12 篇作者统计合作学者相似作者
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mag(2013)
引用23浏览0引用
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semanticscholar(2008)
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Scienceno. 5804 (2006): 1454-1457
Won Do Heo,Takanari Inoue,Wei Sun Park,Man Lyang Kim,Byung Ouk Park, Thomas J. Wandless,Tobias Meyer
Scienceno. 5804 (2006): 1458-1461
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