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Despite the power of modern organic chemistry, efficient synthesis of complex molecular scaffolds remains an unmet challenge. Their intricate ring systems and stereochemical arrays require too many synthetic operations to rapidly produce libraries of analogs. New technological approaches are needed to forge their varied bonds to provide scalable access to libraries of these molecular architectures. Through detailed mechanistic study, such technologies can be developed.
The development of general construction reactions has broad utility in a range of fields that rely on the synthesis of small molecules and functional materials. One particular area that we focus on is the total chemical synthesis of frameworks that are known to elicit powerful neurological effects. These substances serve as chemical probes to study fundamental aspects of neurological function and to address neurological dysfunction.
Despite the power of modern organic chemistry, efficient synthesis of complex molecular scaffolds remains an unmet challenge. Their intricate ring systems and stereochemical arrays require too many synthetic operations to rapidly produce libraries of analogs. New technological approaches are needed to forge their varied bonds to provide scalable access to libraries of these molecular architectures. Through detailed mechanistic study, such technologies can be developed.
The development of general construction reactions has broad utility in a range of fields that rely on the synthesis of small molecules and functional materials. One particular area that we focus on is the total chemical synthesis of frameworks that are known to elicit powerful neurological effects. These substances serve as chemical probes to study fundamental aspects of neurological function and to address neurological dysfunction.
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Yu Shee, Haote Li,Pengpeng Zhang, Andrea Nikolic,Sanil Sreekumar,Frédéric Buono, Jinhua Song,Timothy Newhouse,Victor Batista
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H. Ray Kelly, Sanil Sreekumar, Vidhyadhar Manee, Abbigayle E. Cuomo,Timothy R. Newhouse,Victor S. Batista,Frederic Buono
ACS CATALYSISno. 7 (2024): 5027-5038
Daria E Kim, Yingchuan Zhu,Shingo Harada, Isaiah Aguilar, Abbigayle E Cuomo,Minghao Wang,Timothy R Newhouse
Angewandte Chemie (International ed. in English)no. 39 (2023): e202307455-e202307455
ACS CENTRAL SCIENCEno. 9 (2023): 1768-1774
Alexander W. Schuppe,Yannan Liu, Elsie Gonzalez-Hurtado,Yizhou Zhao,Xuefeng Jiang,Sebastian Ibarraran,David Huang, Xiaoyuan Wang,Jaehoo Lee,J. Patrick Loria,Vishwa Deep Dixit,Xin Li,
SSRN Electronic Journalno. 10 (2022): 2856-2887
crossref(2022)
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