My research interest has been focused on the prevention strategies and psycho-social interventions for dementia. Since 2004, I have been director of the Jockey Club Centre for Positive, a service, training and research centre for people with dementia. Since 2015, I have been following up over 1000 older people with well characterized Alzheimer disease (AD) and mild cognitive impairment for determinants of functional decline in AD.

My other research focus is on fracture prevention and healthy ageing. I am the project leader in a prospective cohort study of 4,000 older men and women, which has been ongoing since 2001. The large data set has shown insights in the risk factors of osteoporosis, fractures, frailty, sarcopenia, functional decline, cognitive decline, atherosclerosis and mortality. In more recent follow-up visits, wrist actigraphy, voice, metabolomics, gut microbiota, brain and spine MRI have been added.