基本信息
浏览量:23
职业迁徙
个人简介
Development of new drugs requires an understanding of the molecular forces that stabilize the structure and govern the interactions of the specific biopolymers to which the drug is targeted. In many pathologies, molecular interactions involved in stabilizing the protein and nucleic acid structures and their complexes are altered. These changes may result from genetic mutations that change a protein’s amino acid sequence or from environmental factors, such as changes in pH, temperature, ion concentrations or the presence of other compounds that may influence the binding properties and the distribution of conformational states sampled by the protein. A better understanding of the physical basis of protein folding and misfolding and the interaction of proteins with their ligands, other proteins and/or nucleic acids will lead to the development of more effective strategies for treatment of diseases.
研究兴趣
论文共 95 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
The Journal of chemical physicsno. 5 (2023)
Biophysical Journalno. 3 (2023): 62-62
JOURNAL OF MOLECULAR LIQUIDS (2023): 122320-122320
引用0浏览0引用
0
0
Handbook of Chemical Biology of Nucleic Acidspp.1-31, (2022)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn