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Waldmann's research has focused on lymphokines, their receptors, and use of lymphokines and monoclonal antibodies to their receptors in the treatment of cancer and of autoimmune diseases. He studied the IL-2/IL-2 receptor system in the growth of normal and neoplastic cells. He co-discovered IL-15 and has initiated clinical trials employing IL-15 in the treatment of metastatic malignancy.
He studied the role played by the receptor for interleukin-2 (IL-2) on the growth, differentiation and regulation of normal and neoplastic T-cells. He defined the IL-2 receptor subunits IL-2R beta and IL-2R alpha using the first reported anticytokine monoclonal antibody (anti-Tac)[3] leading to the definition of the IL-2R alpha as a target for the therapy of leukemia and autoimmune diseases.
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论文共 143 篇作者统计合作学者相似作者
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Bloodno. 15 (2023): 1271-1280
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Journal for ImmunoTherapy of Cancerno. Suppl 1 (2023)
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Bloodno. 15 (2023): 1297-1311
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