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RNA functions not only as a carrier of genetic information, but also as a catalyst and guide for the processing or regulation of other RNA molecules. Cells have evolved mechanisms to sense aberrant sequence, structure, and chemical modification of nucleic acids by a process known as innate immunity. Tuschl is investigating these mechanisms in human cells with the goal of developing treatments for genetic and inflammatory diseases.
Eukaryotic cells express a variety of classes of small RNA molecules. The Tuschl lab has identified these classes and their many members using various RNA-sequencing (RNA-seq) techniques. Their discoveries include the molecular characterization of small interfering RNAs (siRNAs), a class of double-stranded, 21-nucleotide-long molecules that guide sequence-specific gene silencing. Tuschl was the first to demonstrate their utility for knocking down human gene expression, leading to the development of a new class of therapeutics.
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