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Our research program focuses on mechanisms by which metabolic therapy manages chronic diseases such as epilepsy, neurodegenerative lipid storage diseases, and cancer. The metabolic therapies include caloric restriction, fasting, and ketogenic diets. Our approach is based on the idea that compensatory metabolic pathways are capable of modifying the pathogenesis of complex diseases. Global shifts in metabolic environment can neutralize molecular pathology. In the case of cancer, these therapies target and kill tumor cells while enhancing the physiological health of normal cells. The neurochemical and genetic mechanisms of these phenomena are under investigation in novel animal models and include the processes of inflammation, cellular physiology, angiogenesis, and lipid biochemistry.
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论文共 368 篇作者统计合作学者相似作者
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Derek C. Lee,Linh Ta,Purna Mukherjee,Tomas Duraj,Marek Domin, Bennett Greenwood, Srada Karmacharya, Niven R. Narain, Michael Kiebish,Christos Chinopoulos,Thomas N. Seyfried
biorxiv(2024)
Dora Ravasz,David Bui, Sara Nazarian,Gergely Pallag,Noemi Karnok,Jennie Roberts, Bryan P. Marzullo,Daniel A. Tennant, Bennett Greenwood, Alex Kitayev, Collin Hill,Timea Komlódi,
Isabella D. Cooper,Yvoni Kyriakidou,Kurtis Edwards,Lucy Petagine,Thomas N. Seyfried,Tomas Duraj,Adrian Soto-Mota, Andrew Scarborough, Sandra L. Jacome,Kenneth Brookler, Valentina Borgognoni, Vanusa Novaes,
Annals of neurology (2023)
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bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Timothy D. Noakes,Miriam Kalamian,Thomas N. Seyfried,Purna Mukherjee,Dominic P. D’Agostino,Gabriel Arismendi-Morillo,Christos Chinopoulos, Martha Tettenborn, Nasha Winters
Elsevier eBookspp.307-362, (2023)
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Frontiers in nutrition (2023): 1157517
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