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How are memories encoded in the brain? What makes some memories fade and other last a lifetime? Why can we not retain our memories of early childhood? In our lab, we investigate these questions by looking at the activity of neural circuits in the hippocampus and connected brain regions during memory formation and retrieval.
The hippocampus creates episodic memories – defined as memories of events, as well as where and when they occurred. Hippocampus neurons create neural ‘maps’ of places that animals visit, by tuning their firing to an animal’s current position or orientation in space (examples of these neurons include place cells, grid cells and head direction cells). These neural maps are the basis for remembering where events occurred, are necessary if we wish to navigate back to places we remember. Our research aims to understand how these neural maps support memories, with a special interest in how they emerge during post-natal development. A distinctive feature of human development is the loss of all memories preceding approximately 3 years of age (infantile amnesia): can we understand from studying hippocampal networks why this occurs? To address these problems, we use cutting edge technologies to both visualise and manipulate neural circuits during behaviour (tetrode recording, neuropixels silicon probes, 2-photon microscopy and opto- and chemo-genetics).
The hippocampus creates episodic memories – defined as memories of events, as well as where and when they occurred. Hippocampus neurons create neural ‘maps’ of places that animals visit, by tuning their firing to an animal’s current position or orientation in space (examples of these neurons include place cells, grid cells and head direction cells). These neural maps are the basis for remembering where events occurred, are necessary if we wish to navigate back to places we remember. Our research aims to understand how these neural maps support memories, with a special interest in how they emerge during post-natal development. A distinctive feature of human development is the loss of all memories preceding approximately 3 years of age (infantile amnesia): can we understand from studying hippocampal networks why this occurs? To address these problems, we use cutting edge technologies to both visualise and manipulate neural circuits during behaviour (tetrode recording, neuropixels silicon probes, 2-photon microscopy and opto- and chemo-genetics).
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Papers共 29 篇Author StatisticsCo-AuthorSimilar Experts
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Nature Communicationsno. 1 (2024): 1-17
Mattias Horan, Daniel Regester,Cristina Mazuski, Thomas Jahans-Price, Shanice Bailey, Emmett Thompson, Zuzanna Slonina, Viktor Plattner, Elena Menichini, Irmak Toksöz, Sandra Romero Pinto, Mark Burrell,
crossref(2024)
Current Biologyno. 10 (2024): 2256-2264.e3
bioRxiv (Cold Spring Harbor Laboratory) (2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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