Thomas J. Lanza

Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, NJ 07065, USA

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Papers42 papers

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ChemInform Abstract: Enantioselective Approach to 3-Substituted Prolines

Theodore M. Kamenecka,You-Jung Park,Linus S. Lin,Thomas Lanza Jr.,William K. Hagmann

Cheminform, no. 9 (2010)

Cited by7Bibtex

Synthesis and cannabinoid-1 receptor binding affinity of conformationally constrained analogs of taranabant

Ihor E. Kopka,Linus S. Lin,James P. Jewell,Thomas J. Lanza,Tung M. Fong,Chun-Pyn Shen,Zhege J. Lao,Sookhee Ha,Laurie G. Castonguay,Lex Van der Ploeg,Mark T. Goulet,William K. Hagmann

Bioorganic & Medicinal Chemistry Letters, no. 16 (2010): 4757-4761

Cited by3EIWOSBibtex

Substituted pyridyoxy amides

William K Hagmann,Linus S Lin,Shrenik K Shah,Ravindra N Guthikonda,Hongbo Qi,Linda L Chang,Ping Liu, Helen M Armstrong,James P Jewell,Thomas J Lanza

(2008)

Bibtex

Antiobesity Efficacy of a Novel Cannabinoid-1 Receptor Inverse Agonist, N-((1S,2S)-3-(4-Chlorophenyl)-2- (3-cyanophenyl)-1-methylpropyl)-2-methyl-2-{(5-

Tung M Fong,Xiaoming Guan,Donald J Marsh,Chunpyn Shen,D Sloan Stribling, Kim M Rosko,Julie Lao,Yue Feng,Jing Chen Xiao,Lex H T Van Der Ploeg,Mark T Goulet, Williams K Hagmann

(2007)

Bibtex

Antiobesity Efficacy of a Novel Cannabinoid-1 Receptor Inverse Agonist, N-[(1S,2S)-3-(4-Chlorophenyl)-2-(3-cyanophenyl)-1-methylpropyl]-2-methyl-2- propanamide (MK-0364), in Rodents

Tung M Fong,Xiangming Guan,Donald J Marsh,Chepiao Shen,D Sloan Stribling,K. M. Rosko, Julie Z Lao,Herbert Yu,Y J Feng,Jing Chen Xiao,L. H. T. Van der Ploeg,Mark T Goulet

Journal of Pharmacology and Experimental Therapeutics, no. 3 (2007): 1013-1022

Cited by11Bibtex

Substituted acyclic sulfonamides as human cannabinoid-1 receptor inverse agonists

Helen E. Armstrong,Amy Galka,Linus S. Lin,Thomas J. Lanza,James P. Jewell,Shrenik K. Shah,Ravi Guthikonda,Quang Truong,Linda L. Chang,Grace Quaker,Vincent J. Colandrea,Xinchun Tong

Bioorganic & Medicinal Chemistry Letters, no. 8 (2007): 2184-2187

Cited by22EIWOSBibtex

Anti-obesity efficacy of a novel cannabinoid-1 receptor inverse agonist MK-0364 in rodents

Tung M. Fong,Xiao-Ming Guan,Donald J. Marsh,Chun-Pyn Shen,D. Sloan Stribling, Kim Rosko, Julie Z. Lao,Hong Yu, Yue Feng,Jing C. Xiao,Lex H.T. Van der Ploeg,Mark T. Goulet

Journal of Pharmacology and Experimental Therapeutics, (2007)

Bibtex

Effects of mutations at conserved TM II residues on ligand binding and activation of mouse 5-HT 6 receptor

Jiaping Zhang,Chunpyn Shen,Jing Chen Xiao,Thomas J Lanza,Linus S Lin,B Francis,Tung M Fong,Richard Z Chen

European Journal of Pharmacology, no. 1 (2006): 77-82

Bibtex

Effects of mutations at conserved TM II residues on ligand binding and activation of mouse 5-HT6 receptor

Jiaping Zhang,Chun-Pyn Shen,Jing C Xiao,Thomas J Lanza,Linus S Lin,Barbara E Francis,Tung M Fong,Richard Z Chen

European Journal of Pharmacology, no. 1 (2006): 77-82

Cited by6WOSEIBibtex

Bioisosteric replacement of anilide with benzoxazole: potent and orally bioavailable antagonists of VLA-4

Linus S Lin,Thomas J Lanza,Laurie A Castonguay,Theodore Kamenecka,Ermenegilda McCauley,Gail Van Riper,Linda A Egger,Richard A Mumford,Xinchun Tong,Malcolm MacCoss,John A Schmidt,William K Hagmann

Bioorganic & Medicinal Chemistry Letters, no. 9 (2004): 2331-2334

Cited by18EIWOSBibtex

A highly active catalyst system for the heteroarylation of acetone

Ping Liu,Thomas J. Jr. Lanza,James P. Jewell,Carrie P. Jones,William K. Hagmann,Linus S. Lin

Tetrahedron Letters, no. 49 (2003): 8869-8871

EIBibtex

Substituierte amide Substituted amides

William K Hagmann,Linus S Lin,Shrenik K Shah,Ravindra N Guthikonda,Hongbo Qi,Linda L Chang,Ping Liu, Helen M Armstrong,James P Jewell,Thomas J Lanza

(2003)

Bibtex

A Small Molecule α4β1/α4β7 Antagonist Differentiates between the Low-Affinity States of α4β1 and α4β7: Characterization of Divalent Cation Dependence

Linda A Egger,Jin Cao, Christine Mccallum,Usha Kidambi,Gail Van Riper,Ermengilda Mccauley,R Mumford,Thomas J Lanza,Linus S Lin,Stephen E De Laszlo,David N Young,Ginger Yang

Journal of Pharmacology and Experimental Therapeutics, (2003)

Cited by4Bibtex

Substituted amides active at the cannabinoid-1 receptor

William K Hagmann,Linus S Lin,Shrenik K Shah,Ravindra N Guthikonda,Hongbo Qi,Linda L Chang,Ping Liu, Helen M Armstrong,James P Jewell,Thomas J Lanza

(2003)

Cited by28Bibtex

Specific and dual antagonists of α 4 β 1 and α 4 β 7 integrins

Linus S Lin,Thomas J Lanza,Ermenegilda Mccauley,Gail Van Riper,Usha Kidambi,Jin Cao,Linda A Egger,R Mumford,John A Schmidt,Malcolm Maccoss,William K Hagmann

Bioorganic & Medicinal Chemistry Letters, no. 2 (2002): 133-136

Cited by27Bibtex

N-Aryl-prolyl-dipeptides as potent antagonists of VLA-4

Theodore M. Kamenecka,Thomas Lanza, Jr.,Stephen E. de Laszlo,Bing Li,Ermengilda D. McCauley,Gail Van Riper,Linda A. Egger,Usha Kidambi,Richard A. Mumford,Sharon Tong,Malcolm MacCoss,John A. Schmidt

Bioorganic & Medicinal Chemistry Letters, no. 16 (2002): 2205-2208

Cited by12EIWOSBibtex

Effects of VLA-4 antagonists in rat whole embryo culture

Stan Spence,Christine Vetter,William K Hagmann,Gail Van Riper,Hollis Williams,Richard A Mumford,Thomas J Lanza,Linus S Lin,John A Schmidt

Teratology, no. 1 (2002): 26-37

Cited by9WOSBibtex

α4β7/α4β1Dual Integrin Antagonists Block α4β7-Dependent Adhesion under Shear Flow

Linda A Egger,Usha Kidambi,Jin Cao,Gail Van Riper,Ermengilda Mccauley,R Mumford,Suzanne E Amo,Russell B Lingham,Thomas J Lanza,Linus S Lin,Stephen E De Laszlo,David N Young

Journal of Pharmacology and Experimental Therapeutics, (2002)

Cited by9Bibtex

N-(arylacetyl)-biphenylalanines as potent VLA-4 antagonists

Bing Li,Stephen E de Laszlo,Theodore M Kamenecka,Ihor E Kopka,Philippe L Durette,Thomas Lanza,Malcolm MacCoss,Sharon Tong,Richard A Mumford,Ermengilda D McCauley,Gail Van Riper,John A Schmidt

Bioorganic & Medicinal Chemistry Letters, no. 16 (2002): 2141-2144

Cited by18WOSEIBibtex

CorrigendumCorrigendum to “The discovery of acylated β-Amino acids as potent and orally bioavailable VLA-4 antagonists”[Bioorg. Med. Chem. Lett. 12 (2002) 611]

Linus S Lin,Ihor E Kopka,Richard A Mumford,Plato A Magriotis,Thomas Lanza, Jr,Philippe L Durette,Theodore Kamenecka,David N Young,Stephen E de Laszlo,Ermenegilda McCauley,Gail Van Riper,Usha Kidambi

Bioorganic & Medicinal Chemistry Letters, no. 12 (2002): 1695-1695

EIBibtex

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