His research is aiming at innovative analytical tools for metabolomics-driven systems biology in personalized health strategies.

In recent years he developed tools to detect, quantify and identify as many as possible metabolites in mammalian biofluids, tissues and cells. His research aims at improving sample preparation and multi-dimensional chromatographic and electro-driven separation methods, improving the interfacing to mass spectrometry, miniaturizing analytical methods using micro/nano-technology and developing methods for the identification of metabolites. He has developed several innovative technologies for miniaturized and high throughput metabolomics, for which he also holds a few patents.

In collaboration with clinicians, biomedical researchers, biostatisticians and other –omics researchers he works on better (early) diagnosis and interventions for (cardio)vascular and metabolic diseases and neurological diseases.