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Our laboratory investigates the molecular basis of cellular motility and cytokinesis. Actin-based cellular movements are essential for shaping organs during embryonic development, defense against microorganisms, and wiring the nervous system. Movement of cells out of primary tumors is the chief cause of mortality in cancer. Cytokinesis is essential for the replication of all cells and is still one of the least understood aspects of cell division. Half of the lab studies how assembly of actin filaments pushes forward the leading edge of motile cells and moves coated vesicles into cells. We discovered that Arp2/3 complex is both the central integrator of inputs from signaling pathways and initiator of actin filament assembly. Half of the lab uses fission yeast to study cytokinesis, still one of the most mysterious of cellular processes. We mapped the spatial and temporal pathway for the assembly of more than a dozen proteins in the equatorial contractile ring of actin filaments and myosin-II and are investigating how a formin protein mediates actin assembly and how cells trigger constriction of the ring at the end of mitosis.
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论文共 414 篇作者统计合作学者相似作者
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bioRxiv : the preprint server for biology (2024)
Sai Shashank Chavali,Steven Z. Chou,Wenxiang Cao,Thomas D. Pollard,Enrique M. De La Cruz,Charles V. Sindelar
Nature Communicationsno. 1 (2024): 1-1
Sai Shashank Chavali,Steven Z. Chou,Wenxiang Cao,Thomas D. Pollard,Enrique M. De La Cruz,Charles V. Sindelar
Nature Communicationsno. 1 (2024): 1-12
FEBS Lettersno. 5 (2023): 672-681
Frontiers in Physiology (2023): 1324623-1324623
bioRxiv : the preprint server for biology (2023)
Thoru Pederson,Thomas D. Pollard, William C. Earnshaw, Jennifer Lippincott-Schwartz, Graham T. Johnson
FASEB JOURNALno. 9 (2023)
Proceedings of the National Academy of Sciences of the United States of Americano. 49 (2022): e2206722119-e2206722119
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