基本信息
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个人简介
Biopolymers have a surprising number of responsibilities in our body; they hold cells together to form tissues, they provide subtle chemical signals to cells to guide their behavior, they contribute to the skin’s hydration and elasticity, they lubricate our joints and gastrointestinal tracts, and protect us against toxins and pathogens by assembling into the mucus gel that covers our eyes and respiratory tract.
We seek to understand how these natural materials provide the wide range of functionalities they exhibit in our body. We then engineer new materials that mimic or enhance these functionalities.
We are particularly fascinated by the MUCIN biopolymers. Mucins are glycoproteins (~40% protein, ~60% sugars) that form the mucus gels. A better understanding of how mucins work is key to address the many mucus-related diseases, including cystic fibrosis and inflammatory bowel diseases.
The mucins covering our epithelium hydrate, lubricate, protect, and modulate cell behaviors (see our outreach page to learn more about mucins). As such, mucins may also become reference biopolymers for new generations of functional biomaterials.
We can harvest mucins from animal secretions or tissues including humans saliva, snails slime, pig stomachs, jellyfish, and many others.
研究兴趣
论文共 65 篇作者统计合作学者相似作者
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Abby Weston,Sorin-Cristian Vladescu,Tom Reddyhoff, Alex Griffiths,Thomas Crouzier, Matthew Fielden,James A. Garnett,Guy H. Carpenter
Colloids and Surfaces B: Biointerfaces (2023): 113327-113327
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Raimunda Samia Nogueira Brilhante,Anderson da Cunha Costa,Jaco Ricarte Lima de Mesquita,Gessica dos Santos Araujo, Rosemeyre Souza Freire,Joao Victor Serra Nunes, Augusto Feynman Dias Nobre,Mirele Rodrigues Fernandes,Marcos Fabio Gadelha Rocha, Waldemiro de Aquino Pereira Neto,Thomas Crouzier,Ulrike Schimpf,
JOURNAL OF FUNGIno. 12 (2023): 1201
Nature Materialsno. 7 (2023): 803-804
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ACS applied bio materialsno. 9 (2023): 3696-3705
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