My colleagues and I have developed algorithms and software for analyzing X-ray diffraction and cryo-EM data from macromolecules such as proteins and nucleic acids and determining their 3-dimensional structures. I am part of the collaborative Phenix project, an effort led by Paul Adams at LBL that has produced a comprehensive software package for macromolecular structure determination. The Phenix package includes my SOLVE/RESOLVE software as well as many additional powerful algorithms, including maximum-likelihood molecular replacement (Randy Read's Phaser software), full maximum-likelihood refinement (Paul Adams, Ralf Grosse-Kunstleve, and Pavel Afonine's phenix.refine), model improvement and validation (the Richardson laboratory's Molprobity software) and many other useful tools. The Phenix software is available free for academic users.