We focus our research on lymphocyte interactions in vivo. We are especially interested in Dendritic Cell (DC) biology and the immune responses resulting from DC and T lymphocytes' interactions. More precisely, we are studying the role of DCs in the induction of immunity and tolerance. Here we exploit various models of human diseases to analyze the development, function, and biology of DCs and extracellular vesicles as biomarkers and their potential immunomodulatory effects.