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个人简介
I am an expert in infectious diseases, and I care for hospitalized patients at the Buffalo VA Medical Center (Buffalo VAMC).
I have an active, nationally funded translational research program. My research focuses on Gram-negative bacilli (GNB), including Escherichia coli, Acinetobacter baumannii and a new hypervirulent variant of Klebsiella pneumoniae.
These GNB cause infection in nearly every non-intestinal site in the body. The hypervirulent variant of K. pneumoniae is both fascinating and worrisome. Unlike its predecessors, it is capable of causing infection in young, healthy hosts and spreading nearly anywhere in the body from the initial infected site, including the eyes and brain. GNB-caused infections result in the loss of billions of health care dollars, millions of work days and hundreds of thousands of lives each year.
GNB are becoming increasingly resistant to antibiotics, including strains that have become resistant to all available antibiotics. Unfortunately, there are virtually no new antimicrobial agents active against highly resistant GNB in the pharmaceutical “pipeline.” To address this formidable clinical challenge, my collaborators and I have increased our understanding of the bacterial factors that are critical for these GNB to cause infection. We use this information to develop vaccines that will prevent infection and antibodies that can be used to treat infection. My UB collaborators include Dr. Campagnari (microbiology) and Dr. Gulick (structural biology). My research also involves identifying potential bacterial drug targets; this information will be used to develop new classes of antibiotics.
研究兴趣
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Thomas A Russo,Ulrike Carlino-MacDonald,Cassandra L Alvarado,Connor J Davies, Oscar Barnes,Grishma Trivedi, Parijat Mathur,Alan Hutson,Felise G Adams,Maoge Zang,Alice Ascari,Bart A Eijkelkamp
FEMS microbes (2023)
Ashish Kumar,Taihao Yang,Somnath Chakravorty,Aritri Majumdar,Brittany L Nairn,David A Six, Naara Marcondes Dos Santos,Sarah L Price,Matthew B Lawrenz,Luis A Actis,Marilis Marques,Thomas A Russo,
Transforming Global Healthpp.213-228, (2020)
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