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Tom went on to do postdoctoral studies at The Rockefeller University (NY, USA) with Dr. C. David Allis where he worked on the epigenetics of MLL leukaemias. He then became a Group Leader in 2010 at the MRC Molecular Haematology Unit (MRC Weatherall Institute of Molecular Medicine, The University of Oxford, Oxford, UK) and became an Associate Professor of Haematology in 2014. The Milne lab's major area of interest is in epigenetics and gene regulation in leukaemia. Patients with mutations in the MLL gene do not respond well to conventional therapies and thus have very poor survival rates. This is likely due to the fact that MLL is a master regulator that modifies the epigenetic information content of a cell. The overall goal of the Milne lab is to use MLL leukaemias as a system to identify and analyze novel epigenetic pathways in leukaemia and to understand how they interact with transcription factor networks. The end goal will be to use this information to identify potentially novel druggable targets.
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论文共 135 篇作者统计合作学者相似作者
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Current Opinion in Genetics & Development (2024): 102191-102191
biorxiv(2024)
Laia Josa-Culleré,Sébastien R G Galan,Thomas J Cogswell,Thomas R Jackson,Morgan Jay-Smith, Laura Mola, Christopher R Greaves,Tom S Carter,Katrina S Madden, Sophie Trott,Douzi Zhang,Carole J R Bataille,
European journal of medicinal chemistry (2023): 115509-115509
crossref(2023)
Hira Mayet, Catriona Gilmour Hamilton, Adam Holloway,Anne Goriely,Christian Babbs, John Ansell, Penny Clarke, Sally Jeans,Thomas Milne,Noemi B. A. Roy
BRITISH JOURNAL OF HAEMATOLOGY (2023): 77-78
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John Pollard, Graham Craggs,Gillian Farnie, Matthew Fawkes,Oleg Fedorov,Charline Giroud, Fenella Gross,Joe Harman, Alison Maloney,Thomas Arthur Milne, Iain Simpson
BLOOD (2023)
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Emily Georgiades,Caroline L. Harrold,Nigel Roberts,Mira Kassouf,Simone G. Riva, Edward Sanders,Helena S. Francis,Joseph Blayney,A. Marieke Oudelaar,Thomas A. Milne,Douglas R. Higgs,Jim Hughes
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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crossref(2023)
Bloodno. 20 (2023): 1752-1756
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