My principal research focus since moving to Stanford has been the identification of the genomic determinants of coronary heart disease (CHD) and risk factors of CHD. This transition in my research focus occurred thanks to the sage advice and unique opportunities provided to me by Dr. Thomas Quertermous, former chief of the Division of Cardiovascular Medicine and my primary mentor for many years after my arrival to Stanford. Since that transition, I have devoted a majority of my time performing advanced population based studies on the genomic causes of heart attacks and the common conditions that predispose people to heart attacks including high cholesterol, smoking, diabetes, obesity, high blood pressure, and insulin resistance. These research efforts go beyond the standard genetic variant association analyses and include analyses, interpretation, and integration of multi-omic data, construction and validation of polygenic scores, as well as Mendelian randomization, epigenetic association, and gene set enrichment analyses to help identify novel pathways of CHD in diverse populations.