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The Powley laboratory team has taken a leadership role in developing and refining the newest neuroscience and neuroanatomical protocols for characterizing the autonomic innervation of the GI tract. Much of their work has focused directly on the circuitry of the stomach.
The team has published a number of papers on adaptations of tracer techniques, immunohistochemistry, and microscopy, and it has used those methods to advance the understanding of the neural circuits which control the upper GI tract and provide brain-gut coordination. One illustration of the Powley laboratory’s contribution is the present understanding of vagal afferent receptors in the gut wall. When the team began its analyses of the extrinsic projections to the gut, only one type of vagal sensory ending in the GI tract wall was defined structurally and characterized morphologically; five have now been described. Of these five, the Powley team is responsible for isolating, characterizing, naming and mapping four of the five receptor types. Another example of the team’s progress, one focused on efferent innervation, is its recent characterization of the vagal motor units that execute the programs of esophageal peristalsis that are generated in the brainstem and projected directly to the muscle sheets of the esophagus.
The team has published a number of papers on adaptations of tracer techniques, immunohistochemistry, and microscopy, and it has used those methods to advance the understanding of the neural circuits which control the upper GI tract and provide brain-gut coordination. One illustration of the Powley laboratory’s contribution is the present understanding of vagal afferent receptors in the gut wall. When the team began its analyses of the extrinsic projections to the gut, only one type of vagal sensory ending in the GI tract wall was defined structurally and characterized morphologically; five have now been described. Of these five, the Powley team is responsible for isolating, characterizing, naming and mapping four of the five receptor types. Another example of the team’s progress, one focused on efferent innervation, is its recent characterization of the vagal motor units that execute the programs of esophageal peristalsis that are generated in the brainstem and projected directly to the muscle sheets of the esophagus.
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Microsystems & Nanoengineeringno. 1 (2024): 1-14
American journal of physiology. Regulatory, integrative and comparative physiologyno. 3 (2023): R305-R316
The Journal of comparative neurologyno. 16 (2023): 1608-1632
Scientific Reportsno. 1 (2023): 1-22
ADVANCED HEALTHCARE MATERIALSno. 19 (2023): e2202619-e2202619
bioRxiv : the preprint server for biology (2023)
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