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Their research priority was identified by the Malawi Ministry of Health, cerebral malaria in Malawian children, and their focus was on malaria pathogenesis, with the ultimate goal being to improve the outcomes (both short and long term) of Malawian children with cerebral malaria.
Over the ensuing decades, they established and validated the Blantyre Coma Score, characterized the clinical syndrome in detail (including malarial retinopathy, in conjunction with Prof. Simon Harding and Dr. Susan Lewallen), conducted an autopsy-based study of clinicopathological correlates of cerebral malaria (with Prof. Sebastian Lucas and Dr. Dan Milner), and incorporated magnetic resonance imaging (MRI), which highlighted a strong association between increased brain volume and death. The Blantyre-based team is currently in the throes of an interventional clinical trial in children with retinopathy-positive cerebral malaria and increased brain volume (per MRI).
The clinical malaria work in Blantyre started as a collaboration between Drs. Taylor and Molyneux, and remains a vibrant collaborative activity involving faculty and students from Michigan State University and the Liverpool School of Tropical Medicine.
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Nature Medicinepp.1-2, (2024)
Malaria journalno. 1 (2023): 125-16
Critical Care Medicineno. 1 (2023): 260-260
Danni Tu,Manu S. Goyal,Jordan D. Dworkin,Samuel Kampondeni,Lorenna Vidal, Eric Biondo-Savin, Sandeep Juvvadi,Prashant Raghavan,Jennifer Nicholas,Karen Chetcuti,Kelly Clark, Timothy Robert-Fitzgerald,
Raquel Furtado, Mahinder Paul,Jinghang Zhang,Joowhan Sung, Paul Karell,Ryung S. Kim,Sophie Caillat-Zucman,Li Liang,Philip Felgner,Andy Bauleni,Syze Gama,Andrea Buchwald,
Nature Communicationsno. 1 (2023): 1-20
MALARIA JOURNALno. 1 (2023): 1-8
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Rachel L. Smith,Allison K. Ikeda, Carol A. Rowley,Amit Khandhadia,Alexander M. Gorbach, Yamikani Chimalizeni,Terrie E. Taylor,Karl Seydel,Hans C. Ackerman
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