基本信息
浏览量:12
职业迁徙
个人简介
Research
Tara Spires-Jones’ research focuses on the mechanisms and reversibility of neurodegeneration in Alzheimer’s disease, other degenerative brain diseases, and ageing. Working with a vibrant group of researchers, she is trying to understand why synapses and neurons become dysfunctional and die in these diseases in order to develop effective therapeutic strategies. Her work has shown that soluble forms of the pathological proteins amyloid beta and tau contribute to synapse degeneration, and that lowering levels of these proteins can prevent and reverse phenotypes in model systems. Further, she has pioneered high-resolution imaging techniques in human post-mortem brain and found evidence that these proteins accumulate in synapses in human disease. Tara Spires-Jones has published over 100 peer reviewed papers which have been cited over 13,000 times.
Tara Spires-Jones’ research focuses on the mechanisms and reversibility of neurodegeneration in Alzheimer’s disease, other degenerative brain diseases, and ageing. Working with a vibrant group of researchers, she is trying to understand why synapses and neurons become dysfunctional and die in these diseases in order to develop effective therapeutic strategies. Her work has shown that soluble forms of the pathological proteins amyloid beta and tau contribute to synapse degeneration, and that lowering levels of these proteins can prevent and reverse phenotypes in model systems. Further, she has pioneered high-resolution imaging techniques in human post-mortem brain and found evidence that these proteins accumulate in synapses in human disease. Tara Spires-Jones has published over 100 peer reviewed papers which have been cited over 13,000 times.
研究兴趣
论文共 185 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Martí Colom-Cadena,Jamie Toombs, Elizabeth Simzer, Kristjan Holt,Robert McGeachan,Jane Tulloch,Rosemary J. Jackson,James H. Catterson, Maxwell P. Spires-Jones,Jamie Rose,Lora Waybright,Anthony O. Caggiano,
Acta Neuropathologicano. 1 (2024): 1-22
Brain communicationsno. 3 (2023)
Cell Reports Medicineno. 7 (2023): 101111-101111
IBRO Neuroscience Reports (2023): S458-S458
Marti Colom-Cadena,Caitlin Davies,Sonia Sirisi,Ji-Eun Lee,Elizabeth M. Simzer,Makis Tzioras,Marta Querol-Vilaseca, Erika Sanchez-Aced, Ya Yin Chang, Kristjan Holt,Robert I. McGeachan,Jamie Rose,
BRAIN COMMUNICATIONSno. 1 (2023): fcad335-fcad335
Cell reports. Medicineno. 9 (2023): 101175-101175
BRAIN COMMUNICATIONSno. 2 (2023): fcad028-fcad028
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn