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Rather than living as single, isolated cells in liquid cultures, most bacteria on this planet form macroscopic, surface-attached, multi-cellular communities known as biofilms. Bacterial biofilms play a role in many diseases and medical conditions including cystic fibrosis, bone, wound and urinary tract infections. Bacterial cells in a biofilm community show increased tolerance to antibiotics, making medical treatment difficult. Understanding this fundamental bacterial developmental process is therefore critical to understand the colonization process of pathogenic bacteria.
The goal of our group is to apply structural and cell biology techniques to study general principles governing bacterial biofilm formation. We use electron cryomicroscopy (cryo-EM) and tomography (cryo-ET) to resolve structures of molecules that mediate biofilm formation. Correlated light and electron microscopy (CLEM) and mass spectrometry (MS) are used to support our investigations. We combine in vitro reconstitution of key molecules with in vivo imaging to understand how bacteria form biofilms.
The goal of our group is to apply structural and cell biology techniques to study general principles governing bacterial biofilm formation. We use electron cryomicroscopy (cryo-EM) and tomography (cryo-ET) to resolve structures of molecules that mediate biofilm formation. Correlated light and electron microscopy (CLEM) and mass spectrometry (MS) are used to support our investigations. We combine in vitro reconstitution of key molecules with in vivo imaging to understand how bacteria form biofilms.
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论文共 74 篇作者统计合作学者相似作者
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Science advancesno. 7 (2024): eadl4628-eadl4628
Alister Burt, Bogdan Toader, Rangana Warshamanage,Andriko von Kugelgen, Euan Pyle,Jasenko Zivanov,Dari Kimanius,Tanmay A.M. Bharat,Sjors Scheres
biorxiv(2024)
crossref(2024)
Olivia E. R. Smith,Tanmay A. M. Bharat
biorxiv(2023)
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biorxiv(2023)
Hannah Ochner,Tanmay A. M. Bharat
STRUCTUREno. 11 (2023): 1297-1305
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