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The 2018 Nobel Prize in Physiology or Medicine was awarded to Drs. Tasuku Honjo and James P. Allison for their discovery of cancer therapy by inhibition of negative immune regulation. They demonstrated that the targeted blockade of inhibitory co-receptors, PD-1 and CTLA-4 can destroy tumors by activating tumor-specific T cells. I have engaged in researches such as the identification of PD-1 ligands, elucidation of the inhibitory mechanism of PD-1, dissection of the pathomechanisms of autoimmune diseases that PD-1KO mice develop, and treatments of cancer by PD-1 blockade in Dr. Honjo’s laboratory. Through these researches, PD-1 has been established as an inhibitory co-receptor of lymphocytes and proposed to be a promising target of cancer immunotherapy.
Stimulatory and inhibitory co-receptors tightly control the activation of lymphocytes by regulating the quality and the quantity of the antigen receptor signaling to optimize beneficial immune responses while avoiding autoimmunity and excess immune responses. In addition to PD-1 and CTLA-4, many other co-receptors have been identified and regarded as potential drug targets. Although these co-receptors are supposed to have unique function and cooperate each other, their functional differences and coordination remain to be clarified. The primary aim of our laboratory is to elucidate the molecular and cellular mechanisms of PD-1 as well as other co-receptors in the regulation of immune responses. By fully understanding the regulatory mechanisms of immune system, we believe we can manipulate immune responses precisely to control various diseases such as cancer and autoimmune diseases.
Stimulatory and inhibitory co-receptors tightly control the activation of lymphocytes by regulating the quality and the quantity of the antigen receptor signaling to optimize beneficial immune responses while avoiding autoimmunity and excess immune responses. In addition to PD-1 and CTLA-4, many other co-receptors have been identified and regarded as potential drug targets. Although these co-receptors are supposed to have unique function and cooperate each other, their functional differences and coordination remain to be clarified. The primary aim of our laboratory is to elucidate the molecular and cellular mechanisms of PD-1 as well as other co-receptors in the regulation of immune responses. By fully understanding the regulatory mechanisms of immune system, we believe we can manipulate immune responses precisely to control various diseases such as cancer and autoimmune diseases.
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论文共 108 篇作者统计合作学者相似作者
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Immunityno. 5 (2022): 912-924.e8
Jehanne Hassan,Elizabeth Appleton,Bahire Kalfaoglu,Malin Pedersen,José Almeida-Santos, Hisashi Kanemaru, Nobuko Irie,Shane Foo,Omnia Reda,Benjy J.Y. Tan,Il-mi Okazaki,Taku Okazaki,
biorxiv(2022)
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Proceedings of the National Academy of Sciences of the United States of Americano. 35 (2021)
Shimizu Kenji, Sugiura Daisuke, Okazaki Il-mi, Maruhashi Takumi,Takegami Yujiro, Cheng Chaoyang, Ozaki Soichi,Okazaki Taku
Molecular Cellno. 5 (2020): 937-950
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