Research
The major goal of our laboratory is to understand the molecular basis of Alzheimer’s disease (AD) using a multidisciplinary approach based on molecular, cellular and chemical biology. We are also conducting translational research aimed at the discovery and pre-clinical development of novel therapies for AD. Several cellular disease models are being used, including mouse embryonic stem (ES) cell-derived neurons as an alternative to primary cortical neurons for small molecule screening and functional genetic analyses. Relevant mouse models are also being utilized.