基本信息
浏览量:88
职业迁徙
个人简介
After obtaining a BSc (Hons) in Biochemistry from University College Swansea I subsequently took up a research position at the National Institute of Medical Research (MRC, Mill Hill), focusing on spinal cord regeneration under supervision of Professor Geoff Raisman. I then moved to the Institute of Neurology working under the supervision of Professor Tamas Revesz, initially studying progressive supranuclear palsy and the different tau isoforms. The project focus shifted towards two hereditary neurodegenerative diseases familial British dementia (FBD) and familial Danish dementia (FDD). Completing my PhD in 2006 investigating the pathology of FBD and FDD providing detailed information about amyloid formation in the brain in these rare conditions, which have similar neuropathological features to those of Alzheimer’s disease (AD) thus providing a model of AD. I am currently focusing my research on frontotemporal dementias (FTLD) currently funded by the Alzheimer’s Research UK senior fellowship. FTLD's are a large group of dementia's characterized by the deposition of several different proteins. Initial work was carried out to re-diagnose archival cases with the new classifications set out by the FTLD working group. Comparing the underlying pathology with detailed clinical histories therefore enabling a more accurate diagnosis in life for future patients. Work has now progressed into investigating how the pathological proteins are involved in FTLD, with particular interest in the proteins TDP-43 and FUS and their role in nuclear transport. My research team has expanded to cover many different disciplines including neuropathology, multi-omics approaches and epigenetics to understand the initiating processes in different neurodegenerative diseases.
研究兴趣
论文共 358 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
Alessandro Marrero-Gagliardi, Judith Noda,Matteo Zanovello, Jose M Brito Armas,Alexander Bampton,Pascual Torres, Carlos Perez, Felipe Fumagallo, Lucas Taoro, Ramon A. Munoz de Bustillo Alfaro, Anna L. Brown, Gregoire Quinet,
biorxiv(2024)
Daisy Sproviero, Cesar Ernesto Payan Gomez,Chiara Milanese,Shixiang Sun,Akos Gyenis, Domenico Delia,Tammaryn Lashley,Jan Vijg,Jan H.J. Hoeijmakers,Pier Giorgio Mastroberardino
medrxiv(2024)
Huihui Luo, Emil K. Gustavsson,Hannah Macpherson,Natalia Dominik,Kristina Zhelcheska,Kylie Montgomery, Claire Anderson,Wai Yan Yau,Stephanie Efthymiou,Chris Turner,Michael DeTure,Dennis W. Dickson,
biorxiv(2024)
Rebecca Andrews, Bin Fu,Christina E. Toomey, Jonathan C. Breiter,Joanne Lachica, Ru Tian, Joseph S. Beckwith,Lisa-Maria Needham, Gregory J. Chant, Camille Loiseau, Angèle Deconfin, Kenza Baspin,
biorxiv(2024)
Bin Fu, Emma E Brock, Rebecca Andrews, Jonathan C Breiter, Ru Tian,Christina E Toomey,Joanne Lachica,Tammaryn Lashley,Mina Ryten,Nicholas W Wood,Michele Vendruscolo,Sonia Gandhi,
Marian Hruska-Plochan,Vera I. Wiersma, Katharina M. Betz,Izaskun Mallona,Silvia Ronchi,Zuzanna Maniecka, Eva-Maria Hock,Elena Tantardini,Florent Laferriere,Sonu Sahadevan,Vanessa Hoop,Igor Delvendahl,
Ashling Giblin, Alexander J Cammack,Niek Blomberg, Alla Mikheenko, Mireia Carcole, Rachel Coneys, Lele Zhou,Yassene Mohammed, Damien Olivier-Jimenez, Magda L Atilano,Teresa Niccoli,Alyssa N Coyne,
biorxiv(2024)
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn