Tom’s research focusses on understanding how tumours arise and develop. The investigations began through interrogating the clonality of copy number events in multiple individual tumours to gain a consensus order in which these events occur.

Recent investigations have focussed on understanding the single cell multicellular environment of the normal and cancerous kidneys. The generation of RNA sequencing data from many hundreds of thousands of single cells has reveal multiple insights into immune function, kidney epithelial cell function, and oncogenesis.