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个人简介
Starzl's most notable accomplishments include:
Performing the first human liver transplant in 1963, and the first successful human liver transplant in 1967, both at the University of Colorado Health Sciences Center.
Establishing the clinical utility of ciclosporin (cyclosporine) in 1982, and tacrolimus in 1991, both leading to FDA approval;
Development of multiple technical advances in organ preservation, procurement and transplant;
Delineating the indications and limitations of abdominal organ transplantation;
Defining the underlying basis for organ transplantation as a treatment of inherited metabolic diseases (thus providing the rationale for current-day gene therapy efforts), specifically for familial hypercholesterolemia, as in the case of Stormie Jones;
Recognizing the causative role of immunosuppression in the development of post-transplant lymphoproliferative disease and other opportunistic infections and the utility of reversing the immunosuppressed state as the principal treatment;
Performing the first simultaneous heart and liver transplant on six-year-old Stormie Jones at Children's Hospital of Pittsburgh in 1984;
Proposing microchimerism in organ transplant tolerance.
Performing the first human liver transplant in 1963, and the first successful human liver transplant in 1967, both at the University of Colorado Health Sciences Center.
Establishing the clinical utility of ciclosporin (cyclosporine) in 1982, and tacrolimus in 1991, both leading to FDA approval;
Development of multiple technical advances in organ preservation, procurement and transplant;
Delineating the indications and limitations of abdominal organ transplantation;
Defining the underlying basis for organ transplantation as a treatment of inherited metabolic diseases (thus providing the rationale for current-day gene therapy efforts), specifically for familial hypercholesterolemia, as in the case of Stormie Jones;
Recognizing the causative role of immunosuppression in the development of post-transplant lymphoproliferative disease and other opportunistic infections and the utility of reversing the immunosuppressed state as the principal treatment;
Performing the first simultaneous heart and liver transplant on six-year-old Stormie Jones at Children's Hospital of Pittsburgh in 1984;
Proposing microchimerism in organ transplant tolerance.
研究兴趣
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CONTEMPORARY LIVER TRANSPLANTATION: THE SUCCESSFUL LIVER TRANSPLANT PROGRAMpp.3-26, (2017)
SCIENCE OF RECONSTRUCTIVE TRANSPLANTATIONpp.VII-VII, (2015)
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Transplantation of the Liverpp.1227-1244, (2015)
LIVER TRANSPLANTATION: CLINICAL ASSESSMENT AND MANAGEMENT (2014)
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Transplant Internationalno. 2 (2014): 133-136
World Journal of Surgeryno. 7 (2014): 759-782
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