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Bacterial pathogens are a serious and growing threat to human health due to the continued emergence of antibiotic resistance, which limits our ability to treat infections. This threat is exemplified by Staphylococcus aureus, which can infect nearly every tissue in the body and is a leading cause of bone and joint infections, as well as skin and soft tissue infections. During infection pathogens must acquire all their nutrients from the host. This critical task is made more difficult as the host actively restricts essential nutrient availability during infection, starving invaders. However, how nutrient starvation impacts pathogens during infection and the adaptations that allow pathogens to overcome this host defense are unknown. Research in the Kehl-Fie laboratory is interdisciplinary leveraging microbiological approaches, biochemical studies and advanced elemental analysis to answer these questions and identify new opportunities for therapeutic intervention.
Research Interests
Research Topics
Host-Pathogen Interactions, Microbial Physiology, Molecular Evolution, Protein Structure, Regulation of Gene Expression, Signal Transduction
Disease Research Interests
Infectious Diseases
研究兴趣
论文共 67 篇作者统计合作学者相似作者
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EMBO REPORTSno. 10 (2023): e57369-e57369
Saika Hossain,Jacqueline R. Morey,Stephanie L. Neville,Katherine Ganio,Jana N. Radin,Javiera Norambuena, Jeff M. Boyd, Christopher A. McDevitt,Thomas E. Kehl-Fie
MBIOno. 5 (2023)
Research Square (Research Square) (2022)
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