基本信息
浏览量:5
职业迁徙
个人简介
Primary fields of research
The role of bacterial and fungal biofilms in chronic infections
Current research
Basically, bacteria display two life forms during growth and proliferation. In one form, the bacteria appear as single, independent cells (planktonic), and in the other form bacteria are organised in sessile aggregates. The latter form is commonly referred to as the biofilm phenotype. Acute infections are assumed to involve planktonic bacteria, and are generally treatable with antibiotics, though successful treatment depends on accurate and fast diagnosis. However, in cases where the bacteria succeed in forming a biofilm within the human host, the infection often turns out to be untreatable and will develop into a chronic state. The important hallmark of chronic, biofilm-based infections is extreme resistance to antibiotics, as well as a number of other conventional antimicrobial agents and an extreme capacity to evade the host defense. In addition, since the bacteria in chronic infections are aggregated, resistance genes can be passed from one bacterium to the other.
We study the role of bacterial and fungal biofilms in chronic infections both in vitro, animal models and ex vivo material from chronic infections. Our interests are how bacteria initiate biofilms in the human body and why the immune defense seems to fail both in the initial infection and later in the chronic infection. What is the prevalence of bacteria and fungus on implants in general? What is the activity of the microbes in chronic infections and which species are present? We also seek to develop tools and methods to enable fast diagnosis of these infections, for better treatment and possible prevention.
The projects are in close collaboration with clinicians at most of the major hospitals in Denmark.
Projects focussed on these issues are currently funded by: Lundbeckfonden, RegionHovedstadens Udviklingsfond, Faculty of Health Sciences, University of Copenhagen, Gerda og Aage Haenschs Fond and Human Frontier Science Project.
Possible conflicts of interest
I am an consultant for:
1) Smith and Nephew
2) SoftOx
3) Novo Nordisk A/S
4) Coloplast
5) Lohmann & Rauscher
研究兴趣
论文共 370 篇作者统计合作学者相似作者
按年份排序按引用量排序主题筛选期刊级别筛选合作者筛选合作机构筛选
时间
引用量
主题
期刊级别
合作者
合作机构
ACTA ODONTOLOGICA SCANDINAVICAno. 1 (2024): 40-47
Blaine Fritz,Anne-Sofie Halling, Isabel Diaz-Pines Cort,Maria Oberlaender Christensen,Amalie Thorsti Moller Ronnstad, Caroline Meyer Olesen,Mette Hjorslev Knudgaard,Claus Zachariae,Steffen Heegaard,Jacob P. Thyssen,Thomas Bjarnsholt
ANTIMICROBIAL AGENTS AND CHEMOTHERAPYno. 2 (2024): e0138723-e0138723
Peter Ostrup Jensen, Pernille Olsen,Arnold Matovu Dungu, Gertrud Baunbaek Egelund,Andreas Vestergaard Jensen,Pernille Ravn,Birgitte Lindegaard,Frederik Boetius Hertz,Thomas Bjarnsholt,Daniel Faurholt-Jepsen,Mette Kolpen
APMIS (2024)
crossref(2024)
Albert Juan Fuglsang-Madsen,Nicole Lind Henriksen, Elizabeth Serrano Chávez,Lasse Andersson Kvich, Julie Knippel Melsted Birch, Katrine Top Hartmann,Thomas Eriksen,Thomas Bjarnsholt,Hans Gottlieb, Thomas Lars Andresen,Louise Kruse Jensen, Jonas Rosager Henriksen,
The Journal of Infectious Diseases (2024)
Elizabeth C Townsend, J Z Alex Cheong, Michael Radzietza, Blaine Fritz,Matthew Malone,Thomas Bjarnsholt,Karen Ousey, Terry Swanson,Gregory Schultz,Angela L F Gibson,Lindsay R Kalan
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society (2024)
Katrine Top Hartmann, Regitze Lund Nielsen, Freja Cecilie Mikkelsen,Bent Aalbæk,Mads Lichtenberg,Tim Holm Jakobsen,Thomas Bjarnsholt,Lasse Kvich,Hanne Ingmer,Anders Odgaard, Henrik E. Jensen,Louise Kruse Jensen
crossref(2024)
Anne Kristine Servais Iversen,Blaine Gabriel Fritz, Mads Joachim Hansen,Klaus Kirketerp-Moller,Tim Holm Jakobsen,Thomas Bjarnsholt,Mads Lichtenberg
APMISno. 3 (2024): 210-220
加载更多
作者统计
合作学者
合作机构
D-Core
- 合作者
- 学生
- 导师
数据免责声明
页面数据均来自互联网公开来源、合作出版商和通过AI技术自动分析结果,我们不对页面数据的有效性、准确性、正确性、可靠性、完整性和及时性做出任何承诺和保证。若有疑问,可以通过电子邮件方式联系我们:report@aminer.cn