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Research objectives
Unravel molecular mechanisms by which mutations in DNA damage response proteins, such as ATM kinase, lead to progressive neurodegeneration.
Determine how DNA damage and repair contributes to disease progression in the brain.
Discover whether DNA repair deficiencies that lead to different neurodegenerative diseases share a common mechanism.
Identify novel DNA damage response proteins required for the maintenance of homeostasis in the brain.
Unravel molecular mechanisms by which mutations in DNA damage response proteins, such as ATM kinase, lead to progressive neurodegeneration.
Determine how DNA damage and repair contributes to disease progression in the brain.
Discover whether DNA repair deficiencies that lead to different neurodegenerative diseases share a common mechanism.
Identify novel DNA damage response proteins required for the maintenance of homeostasis in the brain.
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论文共 34 篇作者统计合作学者相似作者
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Emily J. Talbot, Lisha Joshi,Peter Thornton, Mahya Dezfouli, Kalliopi Tsafou,Michael Perkinton,Svetlana Khoronenkova
NUCLEIC ACIDS RESEARCHno. 3 (2024): 1188-1206
DNA REPAIR (2024): 103634-103634
Emily Talbot, Lisha Joshi,Peter Thornton, Mahya Dezfouli, Kalliopi Tsafou,Michael S. Perkinton,Svetlana V. Khoronenkova
bioRxiv (Cold Spring Harbor Laboratory) (2023)
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Nucleic Acids Research (2022)
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